Protein Information

Name angiotensin II
Synonyms AGT; ANG II; ANHU; Angiotensin I; Angiotensin II; Angiotensinogen; Angiotensinogen precursor; SERPINA 8…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
3174403 Bkaily G, Peyrow M, Sculptoreanu A, Jacques D, Chahine M, Regoli D, Sperelakis N: Angiotensin II increases Isi and blocks IK in single aortic cell of rabbit. Pflugers Arch. 1988 Sep;412(4):448-50.

Angiotensin II (10 (-8) M) increased the slow inward Ba ++ current, and the addition of an antagonist of Ang II, [( Leu8] Ang II, 10 (-8) M) rapidly reversed the effect of Ang II on IBa.
35(0,1,1,5) Details
11737589 Uchiyama-Tanaka Y, Matsubara H, Nozawa Y, Murasawa S, Mori Y, Kosaki A, Maruyama K, Masaki H, Shibasaki Y, Fujiyama S, Nose A, Iba O, Hasagawa T, Tateishi E, Higashiyama S, Iwasaka T: Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells. Kidney Int. 2001 Dec;60(6):2153-63.

10(0,0,0,10) Details
11108151 Matsubara H, Moriguchi Y, Mori Y, Masaki H, Tsutsumi Y, Shibasaki Y, Uchiyama-Tanaka Y, Fujiyama S, Koyama Y, Nose-Fujiyama A, Iba S, Tateishi E, Iwasaka T: Transactivation of EGF receptor induced by angiotensin II regulates fibronectin and TGF-beta gene expression via transcriptional and post-transcriptional mechanisms. Mol Cell Biochem. 2000 Sep;212(1-2):187-201.

10(0,0,0,10) Details
11139469 Fujiyama S, Matsubara H, Nozawa Y, Maruyama K, Mori Y, Tsutsumi Y, Masaki H, Uchiyama Y, Koyama Y, Nose A, Iba O, Tateishi E, Ogata N, Jyo N, Higashiyama S, Iwasaka T: Angiotensin AT (1) and AT (2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation. Circ Res. 2001 Jan 19;88(1):22-9.


Angiotensin II (Ang II)-mediated signals are transmitted via heparin binding epidermal growth factor (EGF)-like growth factor (HB-EGF) release followed by transactivation of EGF receptor (EGFR).
10(0,0,0,10) Details
12511537 Kurisu S, Ozono R, Oshima T, Kambe M, Ishida T, Sugino H, Matsuura H, Chayama K, Teranishi Y, Iba O, Amano K, Matsubara H: Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis. Hypertension. 2003 Jan;41(1):99-107.


We have previously demonstrated that stimulation of the angiotensin (Ang) II type 2 receptor in vascular smooth muscle cells caused bradykinin production by activating kininogenase in transgenic mice.
5(0,0,0,5) Details
10856308 Murasawa S, Matsubara H, Mori Y, Masaki H, Tsutsumi Y, Shibasaki Y, Kitabayashi I, Tanaka Y, Fujiyama S, Koyama Y, Fujiyama A, Iba S, Iwasaka T: Angiotensin II initiates tyrosine kinase Pyk2-dependent signalings leading to activation of Rac1-mediated c-Jun NH2-terminal kinase. J Biol Chem. 2000 Sep 1;275(35):26856-63.

5(0,0,0,5) Details
7516687 Shapiro MS, Wollmuth LP, Hille B: Angiotensin II inhibits calcium and M current channels in rat sympathetic neurons via G proteins. Neuron. 1994 Jun;12(6):1319-29.

IBa from cell-attached patches was reduced by bath-applied angioII (mean 33%), suggesting use of a diffusible cytoplasmic messenger.
2(0,0,0,2) Details
12397683 Matsubara H, Fujiyama S, Iba O, Amano K, Iwasaka T: [Angiogenesis and angiotensin II: differential postnatal angiogenic activities unmasked by gene-engineered mouse models of angiotensin AT1 and AT2 receptor subtypes]. Nippon Rinsho. 2002 Oct;60(10):1911-5.

2(0,0,0,2) Details
9914387 Seki T, Yokoshiki H, Sunagawa M, Nakamura M, Sperelakis N: Angiotensin II stimulation of Ca2+-channel current in vascular smooth muscle cells is inhibited by lavendustin-A and LY-294002. Pflugers Arch. 1999 Feb;437(3):317-23.

Application of 50 nM AngII significantly increased the amplitude of Ba2+ currents through the voltage-gated Ca2+ channels (IBa) by 34. 5+/-9.1% (n=10) within 1 min.
2(0,0,0,2) Details
11566906 Shibasaki Y, Matsubara H, Nozawa Y, Mori Y, Masaki H, Kosaki A, Tsutsumi Y, Uchiyama Y, Fujiyama S, Nose A, Iba O, Tateishi E, Hasegawa T, Horiuchi M, Nahmias C, Iwasaka T: Angiotensin II type 2 receptor inhibits epidermal growth factor receptor transactivation by increasing association of SHP-1 tyrosine phosphatase. Hypertension. 2001 Sep;38(3):367-72.

2(0,0,0,2) Details
11302725 Matsubara H, Shibasaki Y, Okigaki M, Mori Y, Masaki H, Kosaki A, Tsutsumi Y, Uchiyama Y, Fujiyama S, Nose A, Iba O, Tateishi E, Hasegawa T, Horiuchi M, Nahmias C, Iwasaka T: Effect of angiotensin II type 2 receptor on tyrosine kinase Pyk2 and c-Jun NH2-terminal kinase via SHP-1 tyrosine phosphatase activity: evidence from vascular-targeted transgenic mice of AT2 receptor. Biochem Biophys Res Commun. 2001 Apr 20;282(5):1085-91.

2(0,0,0,2) Details
7047153 Iba K, Morii H, Wada M, Yasumoto R, Kishimoto T, Mitsuhashi T, Hojo K, Okahara T: A case report of pseudohypoparathyroidism (Drezner's type I) associated with probable Bartter's syndrome. Endocrinol Jpn. 1981 Oct;28(5):595-604.


Other findings were normal blood pressure, high levels of plasma renin activity and serum aldosterone, a fall in blood pressure after angiotensin II antagonist infusion, blunted pressor response to angiotensin II infusion and hyperplasia of the juxtaglomerular cells.
1(0,0,0,1) Details
9855640 Oz M, Melia MT, Soldatov NM, Abernethy DR, Morad M: Functional coupling of human L-type Ca2+ channels and angiotensin AT1A receptors coexpressed in xenopus laevis oocytes: involvement of the carboxyl-terminal Ca2+ sensors. Mol Pharmacol. 1998 Dec;54(6):1106-12.

In oocytes expressing only alpha1C,77 channels, application of human angiotensin II (1-10 microM) did not affect the amplitude or kinetics of Ba2+ currents (IBa).
The data suggest that the regulation of recombinant L-type Ca2+ channels by angiotensin is mediated by inositol trisphosphate-induced intracellular Ca2+ release and occurs at the molecular motif responsible for the Ca2+-induced inactivation of the channels.
1(0,0,0,1) Details
9283696 Orallo F: Study of the in vivo and in vitro cardiovascular effects of a hydralazine-like vasodilator agent (HPS-10) in normotensive rats. Br J Pharmacol. 1997 Aug;121(8):1627-36.


HPS-10 (0.3 mM) significantly inhibited the sustained and transient Ba2+ inward current (IBa) recorded in whole-cell clamped rat aortic myocytes. 8.
0(0,0,0,0) Details