| Name | G protein |
|---|---|
| Synonyms | G gamma I; Guanine nucleotide binding protein 2; G protein; GNG 2; GNG2; GNGT 2; GNGT2; Guanine nucleotide binding protein gamma 2… |
| Name | IBA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8046455 | Zong X, Lux HD: Augmentation of calcium channel currents in response to G protein activation by GTP gamma S in chick sensory neurons. J Neurosci. 1994 Aug;14(8):4847-53. However, by utilizing prior observations of the voltage dependence of the inhibitory action we could demonstrate that the G protein-inhibited component of IBa, was still present. |
86(1,1,1,6) | Details |
| 8603123 | Hughes AD, Parkinson NA, Wijetunge S: alpha2-Adrenoceptor activation increases calcium channel currents in single vascular smooth muscle cells isolated from human omental resistance arteries. J Vasc Res. 1996 Jan-Feb;33(1):25-31. Activation of alpha2-adrenoceptors in human vascular smooth muscle cells increases IBa by a mechanism involving a pertussis toxin-sensitive G protein. |
81(1,1,1,1) | Details |
| 9855640 | Oz M, Melia MT, Soldatov NM, Abernethy DR, Morad M: Functional coupling of human L-type Ca2+ channels and angiotensin AT1A receptors coexpressed in xenopus laevis oocytes: involvement of the carboxyl-terminal Ca2+ sensors. Mol Pharmacol. 1998 Dec;54(6):1106-12. The inhibitory effect of angiotensin on IBa was abolished in oocytes that had been preincubated with losartan (an AT1A receptor antagonist) or thapsigargin or injected with 1,2-bis (o-aminophenoxy) ethane-N,N,N',N'-tetraacetate, pertussis toxin, -5'-O-(2-thio) or suggesting that the recombinant alpha1C channels were regulated by angiotensin through G protein-coupled AT1A receptors via activation of the inositol trisphosphate-dependent intracellular Ca2+ release pathway. |
31(0,1,1,1) | Details |
| 9325359 | Cuevas J, Adams DJ: M4 muscarinic receptor activation modulates calcium channel currents in rat intracardiac neurons. J Neurophysiol. 1997 Oct;78(4):1903-12. However, internal perfusion of the cell with 100 microM 5'-O-(2-thiodiphosphate) trilithium salt (GDP-beta-S) or incubation of the neurons in Pertussis toxin (PTX) abolished the modulation of IBa by muscarinic receptor agonists, suggesting the involvement of a PTX-sensitive G-protein in the signal transduction pathway. |
81(1,1,1,1) | Details |
| 8051693 | Doupnik CA, Pun RY: G-protein activation mediates prepulse facilitation of Ca2+ channel currents in bovine chromaffin cells. J Membr Biol. 1994 May;140(1):47-56. In contrast, inactivation of G proteins by intracellular GDP-beta S or pertussis toxin (PTX) pretreatment completely abolished or markedly attenuated facilitation of IBa, respectively. |
35(0,1,1,5) | Details |
| 2460176 | Scott RH, McGuirk SM, Dolphin AC: Modulation of divalent cation-activated ion currents. Br J Pharmacol. 1988 Jul;94(3):653-62. In addition, the activation by GTP-gamma-S of a pertussis toxin-sensitive GTP binding (G)-protein resulted in a steady increase in the Cl- tail current with time, despite a concurrent reduction in IBa. 4. |
32(0,1,1,2) | Details |
| 11018106 | Mark MD, Wittemann S, Herlitze S: G protein modulation of recombinant P/Q-type channels by regulators of G protein signalling proteins. J Physiol. 2000 Oct 1;528 Pt 1:65-77. RGS2 markedly accelerates transmitter-mediated inhibition and recovery from inhibition of Ba2+ currents (IBa) through P/Q-type channels heterologously expressed with the muscarinic acetylcholine receptor M2 (mAChR M2). 3. |
6(0,0,0,6) | Details |
| 11179395 | Zhong J, Hume JR, Keef KD: beta-Adrenergic receptor stimulation of L-type Ca2+ channels in rabbit portal vein myocytes involves both alphas and betagamma G protein subunits. J Physiol. 2001 Feb 15;531(Pt 1):105-15. Peak Ba2+ current (IBa) in freshly isolated rabbit portal vein smooth muscle cells was significantly increased by bath application of 0.5 microM isoproterenol (isoprenaline; ISO) when measured using the whole-cell patch clamp method (53 +/- 3 % increase, n = 15). |
4(0,0,0,4) | Details |
| 1326744 | Dolphin AC: The effect of phosphatase inhibitors and agents increasing cyclic-AMP-dependent phosphorylation on calcium channel currents in cultured rat dorsal root ganglion neurones: interaction with the effect of G protein activation. Pflugers Arch. 1992 Jun;421(2-3):138-45. The amplitude of IBa (GTP gamma S), recorded in the presence of GTP [ gamma S] (200 microM) in the patch pipette solution, is enhanced by external application of forskolin (10 microM), and there is an increase in the proportion of the rapidly activating component of the current. |
3(0,0,0,3) | Details |
| 9348341 | Abdulla FA, Smith PA: Nociceptin inhibits T-type Ca2+ channel current in rat sensory neurons by a G-protein-independent mechanism. J Neurosci. 1997 Nov 15;17(22):8721-8. |
3(0,0,0,3) | Details |
| 9547377 | Stephens GJ, Brice NL, Berrow NS, Dolphin AC: Facilitation of rabbit alpha1B channels: involvement of endogenous Gbetagamma subunits. J Physiol. 1998 May 15;509 ( Pt 1):15-27. Co-expression of the Gbeta1gamma2 subunit, together with the alpha1B/alpha2-delta/beta2a calcium channel combination, resulted in a marked degree of depolarizing prepulse-reversible inhibition of the whole-cell ICa or IBa. The alpha1B (N-type) calcium channel shows strong G protein modulation in the presence of G protein activators or Gbetagamma subunits. |
2(0,0,0,2) | Details |
| 9445007 | Arai T, Matsumoto K, Saitoh K, Ui M, Ito T, Murakami M, Kanegae Y, Saito I, Cosset FL, Takeuchi Y, Iba H: A new system for stringent, high-titer vesicular stomatitis virus G protein-pseudotyped retrovirus vector induction by introduction of Cre recombinase into stable prepackaging cell lines. J Virol. 1998 Feb;72(2):1115-21. |
2(0,0,0,2) | Details |
| 10405362 | Arai T, Takada M, Ui M, Iba H: Dose-dependent transduction of vesicular stomatitis virus G protein-pseudotyped retrovirus vector into human solid tumor cell lines and murine fibroblasts. Virology. 1999 Jul 20;260(1):109-15. |
2(0,0,0,2) | Details |
| 10226153 | Zhong J, Dessauer CW, Keef KD, Hume JR: Regulation of L-type Ca2+ channels in rabbit portal vein by G protein alphas and betagamma subunits. J Physiol. 1999 May 15;517 ( Pt 1):109-20. Cells dialysed with either Galphas or Gbetagamma exhibited significant increases in peak Ba2+ current (IBa) density (148 % and 131 %, respectively) compared with control cells. |
2(0,0,0,2) | Details |
| 10398877 | Morikawa H, Mima H, Uga H, Shoda T, Fukuda K: Opioid potentiation of N-type Ca2+ channel currents via pertussis-toxin-sensitive G proteins in NG108-15 cells. Pflugers Arch. 1999 Aug;438(3):423-6. In order to address this issue, we analyzed the effects of [d-Ala2, d-Leu5]-enkephalin (DADLE) on whole-cell Ba2+ currents (IBa) through voltage-gated Ca2+ channels in NG108-15 neuroblastoma x glioma hybrid cells. |
2(0,0,0,2) | Details |
| 2541856 | Dolphin AC, McGuirk SM, Scott RH: An investigation into the mechanisms of inhibition of calcium channel currents in cultured sensory neurones of the rat by nucleotide analogues and (-)-baclofen. Br J Pharmacol. 1989 May;97(1):263-73. These results support the hypothesis that GABAB receptors are directly coupled to channels by G proteins. The inhibition by GTP-gamma-S is particularly characterized by an abolition of the transient component of calcium channel currents carried either by Ba2+ (IBa) or by Ca2+ (ICa). 2. |
1(0,0,0,1) | Details |
| 9417071 | Titievsky A, Titievskaya I, Pasternack M, Kaila K, Tornquist K: inhibits voltage-operated channels in GH4C1 cells. J Biol Chem. 1998 Jan 2;273(1):242-7. Using the patch-clamp technique in the whole-cell mode, we show that SP inhibits Ba2+ currents (IBa) when 0.1 mM BAPTA is included in the patch pipette. By using the double-pulse protocol (to release possible functional inhibition of the VOCCs by G proteins), we observed that G proteins apparently evoked very little functional inhibition of the VOCCs. |
1(0,0,0,1) | Details |
| 7516687 | Shapiro MS, Wollmuth LP, Hille B: Angiotensin II inhibits and M current channels in rat sympathetic neurons via G proteins. Neuron. 1994 Jun;12(6):1319-29. IBa from cell-attached patches was reduced by bath-applied angioII (mean 33%), suggesting use of a diffusible cytoplasmic messenger. |
1(0,0,0,1) | Details |
| 8865066 | Albillos A, Gandia L, Michelena P, Gilabert JA, del Valle M, Carbone E, Garcia AG: The mechanism of calcium channel facilitation in bovine chromaffin cells. J Physiol. 1996 Aug 1;494 ( Pt 3):687-95. By acting at least on purinergic and opiate receptors, the exocytotic release of ATP and opiates will cause a tonic inhibition of the current through a G-protein-mediated mechanism. A 1:1000 dilution of SVL in the external solution halved the magnitude of IBa and produced a 7-fold slowing of its activation kinetics. |
1(0,0,0,1) | Details |
| 2163275 | Scott RH, Dolphin AC: Voltage-dependent modulation of rat sensory neurone calcium channel currents by G protein activation: effect of a dihydropyridine antagonist. Br J Pharmacol. 1990 Apr;99(4):629-30. The ability of a depolarizing prepulse to increase the rate of activation of IBa has been examined in cultured sensory neurones of the rat. |
1(0,0,0,1) | Details |
| 1653319 | Dolphin AC: Ca2+ channel currents in rat sensory neurones: interaction between nucleotides, cyclic AMP and Ca2+ channel ligands. J Physiol. 1991 Jan;432:23-43. In conclusion, internal GTP gamma S activates G proteins which may interact directly with channels to influence the kinetics of activation and to reduce steady-state inactivation of the channels. This current, termed IBa, GTP gamma S, was slowly activating and showed little inactivation over 100 ms. 2. |
1(0,0,0,1) | Details |
| 12853422 | Koschak A, Reimer D, Walter D, Hoda JC, Heinzle T, Grabner M, Striessnig J: Cav1.4alpha1 subunits can form slowly inactivating dihydropyridine-sensitive L-type Ca2+ channels lacking Ca2+-dependent inactivation. J Neurosci. 2003 Jul 9;23(14):6041-9. Cav1.4alpha1-mediated inward Ba2+ currents (IBa) required the coexpression of alpha2delta1 and beta3 or beta2a subunits and were detected in a lower proportion of transfected cells than Cav1.3alpha1. Cav1.4alpha1 exhibited voltage-dependent, G-protein-independent facilitation by strong depolarizing pulses. |
1(0,0,0,1) | Details |
| 9560456 | Morikawa H, Fukuda K, Mima H, Shoda T, Kato S, Mori K: kinase inhibitors suppress N-type and T-type Ca2+ channel currents in NG108-15 cells. Pflugers Arch. 1998 Jun;436(1):127-32. To this end, the effects of PTK inhibitors on whole-cell Ba2+ currents (IBa) through voltage-gated Ca2+ channels were analysed in differentiated NG108-15 neuroblastoma x glioma hybrid cells. suppressed N-type and T-type currents, sparing L-type current, and its effect was independent of G protein activation. |
1(0,0,0,1) | Details |
| 7623277 | Unno T, Komori S, Ohashi H: Inhibitory effect of muscarinic receptor activation on Ca2+ channel current in smooth muscle cells of guinea-pig ileum. J Physiol. 1995 May 1;484 ( Pt 3):567-81. The results suggest that stimulation of the muscarinic receptor causes a biphasic suppression of the voltage-gated calcium channel currents through a PTX-insensitive G protein in guinea-pig ileal smooth muscle cells. A calcium channel current (IBa), when Ba2+ was used as a charge carrier, was also suppressed by CCh in a biphasic manner, as with ICa. |
1(0,0,0,1) | Details |
| 9824718 | Soldo BL, Moises HC: mu-opioid receptor activation inhibits N- and P-type Ca2+ channel currents in magnocellular neurones of the rat supraoptic nucleus. J Physiol. 1998 Dec 15;513 ( Pt 3):787-804. These results indicate that mu-opioid receptors are negatively coupled to N- and P-type Ca2+ channels in the somatodendritic regions of MNCs, possibly via a membrane-delimited G-protein-dependent pathway. The whole-cell voltage-clamp technique was used to examine opioid regulation of Ba2+ currents (IBa) through voltage-sensitive Ca2+ channels in isolated magnocellular supraoptic neurones (MNCs). |
1(0,0,0,1) | Details |
| 8309795 | Menon-Johansson AS, Berrow N, Dolphin AC: G (o) transduces GABAB-receptor modulation of N-type channels in cultured dorsal root ganglion neurons. Pflugers Arch. 1993 Nov;425(3-4):335-43. High-voltage-activated (HVA) calcium channel currents (IBa) were recorded from acutely replated cultured dorsal root ganglion (DRG) neurons. To investigate which G protein subtype was involved, cells were replated in the presence of anti-G protein antisera. |
1(0,0,0,1) | Details |
| 8308719 | Campbell V, Berrow N, Dolphin AC: GABAB receptor modulation of Ca2+ currents in rat sensory neurones by the G protein G (0): antisense oligonucleotide studies. J Physiol. 1993 Oct;470:1-11. Calcium channel currents (IBa) were recorded in cultured dorsal root ganglion neurones (DRGs), 24-32 h after microinjection with 20-mer phosphorothioate antisense oligonucleotides complementary either to a G alpha o or a G alpha i unique sequence, or with a nonsense sequence. 2. |
1(0,0,0,1) | Details |