Protein Information

Name fra 2
Synonyms FOS like antigen 2; FOSL 2; FOSL2; FRA 2; FRA2; Fos related antigen 2; Fos related antigen 2s

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
9427541 Murakami M, Watanabe H, Niikura Y, Kameda T, Saitoh K, Yamamoto M, Yokouchi Y, Kuroiwa A, Mizumoto K, Iba H: High-level expression of exogenous genes by replication-competent retrovirus vectors with an internal ribosomal entry site. Gene. 1997 Nov 20;202(1-2):23-9.


High-level expression of exogenous genes was also observed in the case of the Hoxa-13 gene in the IR1 vector or the fra-2 gene in the IR2 vector, indicating that the extremely high-level expression characteristic of these vectors is applicable to several exogenous genes.
1(0,0,0,1) Details
1900269 Suzuki T, Hashimoto Y, Okuno H, Sato H, Nishina H, Iba H: High-level expression of human c-jun gene causes cellular transformation of chicken embryo fibroblasts. Jpn J Cancer Res. 1991 Jan;82(1):58-64.


Gel shift analysis using nuclear extracts from DS3-infected CEF revealed that the Fra-2/Jun complex contributes to the basal level of AP-1 DNA binding activity.
1(0,0,0,1) Details
1945831 Suzuki T, Okuno H, Yoshida T, Endo T, Nishina H, Iba H: Difference in transcriptional regulatory function between c-Fos and Fra-2. . Nucleic Acids Res. 1991 Oct 25;19(20):5537-42.

8(0,0,0,8) Details
7862446 Sonobe MH, Yoshida T, Murakami M, Kameda T, Iba H: fra-2 promoter can respond to serum-stimulation through AP-1 complexes. . Oncogene. 1995 Feb 16;10(4):689-96.

7(0,0,0,7) Details
10359014 Murakami M, Ui M, Iba H: Fra-2-positive autoregulatory loop triggered by mitogen-activated protein kinase (MAPK) and Fra-2 phosphorylation sites by MAPK. Cell Growth Differ. 1999 May;10(5):333-42.

6(0,0,0,6) Details
7936655 Foletta VC, Sonobe MH, Suzuki T, Endo T, Iba H, Cohen DR: Cloning and characterisation of the mouse fra-2 gene. Oncogene. 1994 Nov;9(11):3305-11.

6(0,0,0,6) Details
1899576 Yoshida T, Sato H, Iba H: Transcription of fra-2 mRNA and phosphorylation of Fra-2 protein are stimulated by serum. Biochem Biophys Res Commun. 1991 Jan 31;174(2):934-9.

6(0,0,0,6) Details
9188858 Murakami M, Sonobe MH, Ui M, Kabuyama Y, Watanabe H, Wada T, Handa H, Iba H: Phosphorylation and high level expression of Fra-2 in v-src transformed cells: a pathway of activation of endogenous AP-1. Oncogene. 1997 May 22;14(20):2435-44.

5(0,0,0,5) Details
7687344 Yoshida T, Suzuki T, Sato H, Nishina H, Iba H: Analysis of fra-2 gene expression. Nucleic Acids Res. 1993 Jun 11;21(11):2715-21.

5(0,0,0,5) Details
8415709 Kameda T, Akahori A, Sonobe MH, Suzuki T, Endo T, Iba H: JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2. Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9369-73.

3(0,0,0,3) Details
2110368 Nishina H, Sato H, Suzuki T, Sato M, Iba H: Isolation and characterization of fra-2, an additional member of the fos gene family. Proc Natl Acad Sci U S A. 1990 May;87(9):3619-23.

3(0,0,0,3) Details
9569029 Matsumoto K, Saitoh K, Koike C, Narita T, Yasugi S, Iba H: Differential expression of fos and jun family members in the developing chicken gastrointestinal tract. Oncogene. 1998 Mar 26;16(12):1611-6.


From soon after formation of the tubular structure, each gene transcript was localized in distinct domains of the epithelium and mesenchyme in all of these major gastrointestinal organs, independently of the anterior-posterior axis. fra-2 was expressed predominantly in epithelium, which also expressed junD, while low-level expression of junD was also detected in smooth muscle cell precursors in mesenchyme.
2(0,0,0,2) Details
8189491 Suzuki T, Murakami M, Onai N, Fukuda E, Hashimoto Y, Sonobe MH, Kameda T, Ichinose M, Miki K, Iba H: Analysis of AP-1 function in cellular transformation pathways. J Virol. 1994 Jun;68(6):3527-35.


The levels of both Fra-2 and c-Jun expression were elevated two- to fourfold, and hyperphosphorylation of Fra-2 was also observed.
2(0,0,0,2) Details
9149901 Kameda T, Watanabe H, Iba H: C-Jun and JunD suppress maturation of chondrocytes. . Cell Growth Differ. 1997 May;8(5):495-503.


All the known components of chicken AP-1 (c-Fos, Fra-2, c-Jun, and JunD) were detected in both cell types, but the expression level of c-Jun was much higher in LS cells, which are rich in less mature chondrocytes than US cells.
1(0,0,0,1) Details