Protein Information

Name Nociceptin
Synonyms Nociceptin; Nociceptin precursor; OFQ; Orphanin FQ; PNOC; PPNOC; Prepronociceptin; Propronociceptin…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
9547380 Connor M, Christie MJ: Modulation of Ca2+ channel currents of acutely dissociated rat periaqueductal grey neurons. J Physiol. 1998 May 15;509 ( Pt 1):47-58.

Nociceptin (EC50, 5 nM) and baclofen (EC50, 0.8 microM) inhibited IBa in all PAG neurons, while the opioid agonist methionine enkephalin (met-enkephalin; 300 nM-10 microM) inhibited IBa in 40 % of neurons.
150(1,3,4,5) Details
9348341 Abdulla FA, Smith PA: Nociceptin inhibits T-type Ca2+ channel current in rat sensory neurons by a G-protein-independent mechanism. J Neurosci. 1997 Nov 15;17(22):8721-8.

7(0,0,0,7) Details
20025929 Sakoori K, Murphy NP: Reduced degeneration of dopaminergic terminals and accentuated astrocyte activation by high dose methamphetamine administration in nociceptin receptor knock out mice. Neurosci Lett. 2010 Jan 29;469(3):309-13. Epub 2009 Dec 16.


Here, we evaluated the function of endogenous nociceptin/orphanin FQ in these events using nociceptin receptor (NOP) knockout mice.
2(0,0,0,2) Details