| Name | tyrosine hydroxylase |
|---|---|
| Synonyms | Putative tyrosine hydroxylase variant; TH; TH protein; TYH; Truncated tyrosine hydroxylase; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine hydroxylase… |
| Name | IBA |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20025929 | Sakoori K, Murphy NP: Reduced degeneration of dopaminergic terminals and accentuated astrocyte activation by high dose methamphetamine administration in nociceptin receptor knock out mice. Neurosci Lett. 2010 Jan 29;469(3):309-13. Epub 2009 Dec 16. Three days later, brains were immunohistochemically processed to visualize methamphetamine-induced loss of tyrosine hydroxylase (as a marker of damage to terminals), glial fibrillary acidic protein (GFAP, as a marker of astrocytes), and ionized calcium-binding adapter molecule 1 (lba-1, as a marker of microglia) in the striatum. |
2(0,0,0,2) | Details |
| 20353427 | Uchida H, Yokoyama H, Kimoto H, Kato H, Araki T: Long-term changes in the ipsilateral substantia nigra after transient focal cerebral ischaemia in rats. Int J Exp Pathol. 2010 Mar 26. In the present study, we investigated long-term changes in the ipsilateral substantia nigra from 1 up to 20 weeks after 90 min of transient focal cerebral ischaemia in rats, using tyrosine hydroxylase (TH), neuronal nuclei (NeuN), Iba-1, glial fibrillary acidic protein (GFAP) and brain-derived neurotrophic factor (BDNF) immunostaining. |
1(0,0,0,1) | Details |
| 17676428 | Takagi S, Hayakawa N, Kimoto H, Kato H, Araki T: Damage to oligodendrocytes in the striatum after MPTP neurotoxicity in mice. J Neural Transm. 2007;114(12):1553-7. Epub 2007 Aug 6. In our Western blot analysis, four administrations of MPTP at 2-h intervals to mice produced the remarkable loss of TH (tyrosine hydroxylase) protein levels in the striatum after 3 and 7 days. |
1(0,0,0,1) | Details |
| 16846658 | Wada M, Yoshimi K, Higo N, Ren YR, Mochizuki H, Mizuno Y, Kitazawa S: Statistical parametric mapping of immunopositive cell density. Neurosci Res. 2006 Sep;56(1):96-102. Epub 2006 Jul 17. We also applied the same analysis to tyrosine hydroxylase stained sections and detected significant decreases of neurons in the side of MPP+ injection. |
1(0,0,0,1) | Details |
| 18671880 | Yuan WJ, Yasuhara T, Shingo T, Muraoka K, Agari T, Kameda M, Uozumi T, Tajiri N, Morimoto T, Jing M, Baba T, Wang F, Leung H, Matsui T, Miyoshi Y, Date I: Neuroprotective effects of edaravone-administration on 6-OHDA-treated dopaminergic neurons. BMC Neurosci. 2008 Aug 1;9:75. Tyrosine hydroxylase (TH) staining of the striatum and substantia nigra pars compacta revealed that edaravone might exert neuroprotective effects on nigrostriatal dopaminergic systems. |
1(0,0,0,1) | Details |
| 19399894 | Berglof E, Small BJ, Bickford PC, Stromberg I: Beneficial effects of antioxidant-enriched diet for tyrosine hydroxylase-positive neurons in ventral mesencephalic tissue in oculo grafts. J Comp Neurol. 2009 Jul 1;515(1):72-82. |
1(0,0,0,1) | Details |
| 11474650 | Petrov T, Shapiro Y, Baker C, Duff JP, Sanders EJ, Gordon T, Smith PA: Peripheral target contact regulates Ca2+ channels in the cell bodies of bullfrog sympathetic ganglion B-neurons. Auton Neurosci. 2001 Jun 20;89(1-2):74-85. Tyrosine-hydroxylase immunohistochemistry demonstrated that a single injection of 120 mg/kg (6-OHDA) reversibly disconnected bullfrog sympathetic ganglia from their peripheral targets. Calcium channel current in ganglionic B-neurons, (measured at -10 mV; holding potential -60 mnV; Ba2+ as charge carrier; IBa) was reduced. |
1(0,0,0,1) | Details |
| 18343932 | Zecca L, Wilms H, Geick S, Claasen JH, Brandenburg LO, Holzknecht C, Panizza ML, Zucca FA, Deuschl G, Sievers J, Lucius R: Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease. Acta Neuropathol. 2008 Jul;116(1):47-55. Epub 2008 Mar 15. After different survival times (1, 8 or 12 weeks), brain slices from the cerebral cortex or substantia nigra (SN, 1 week) were stained with Iba-1 and/or GFAP antibody to monitor microglial and astrocytic reaction, and with tyrosine hydroxylase (TH) to monitor dopaminergic cell survival (SN group only). |
1(0,0,0,1) | Details |
| 19582534 | Cho Y, Son HJ, Kim EM, Choi JH, Kim ST, Ji IJ, Choi DH, Joh TH, Kim YS, Hwang O: Doxycycline is neuroprotective against nigral dopaminergic degeneration by a dual mechanism involving MMP-3. Neurotox Res. 2009 Nov;16(4):361-71. Epub 2009 Jul 7. In vivo, doxycycline provided neuroprotection of the nigral DAergic neurons following MPTP treatment, as assessed by tyrosine hydroxylase immunocytochemistry and silver staining, and suppressed microglial activation and astrogliosis as assessed by Iba-1 and GFAP immunochemistry, respectively. |
1(0,0,0,1) | Details |