Protein Information

Name CYP1A1
Synonyms AHH; AHRR; Arylhydrocarbon hydroxylase; CP11; CYP 1; CYP1; CYP1A1; CYPIA 1…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
12147272 Iba MM, Nguyen T, Fung J: CYP1A1 induction by pyridine and its metabolites in HepG2 cells. Arch Biochem Biophys. 2002 Aug 15;404(2):326-34.

8(0,0,0,8) Details
11485833 Wei C, Caccavale RJ, Kehoe JJ, Thomas PE, Iba MM: CYP1A2 is expressed along with CYP1A1 in the human lung. . Cancer Lett. 2001 Sep 28;171(1):113-20.

6(0,0,0,6) Details
11166912 Wei C, Cacavale RJ, Kehoe JJ, Thomas PE, Iba MM: CYP1A2 is expressed along with CYP1A1 in the human lung. . Cancer Lett. 2001 Mar 10;164(1):25-32.

6(0,0,0,6) Details
10413312 Iba MM, Alam J, Touchard C, Thomas PE, Ghosal A, Fung J: Coordinate up-regulation of CYP1A1 and heme oxygenase-1 (HO-1) expression and modulation of delta-aminolevulinic acid synthase and tryptophan pyrrolase activities in pyridine-treated rats. Biochem Pharmacol. 1999 Aug 15;58(4):723-34.

5(0,0,0,5) Details
16678472 Iba MM, Fung J, Chung L, Zhao J, Winnik B, Buckley BT, Chen LC, Zelikoff JT, Kou YR: Differential inducibility of rat pulmonary CYP1A1 by cigarette smoke and wood smoke. Mutat Res. 2006 Jul 14;606(1-2):1-11. Epub 2006 May 5.

5(0,0,0,5) Details
9764926 Iba MM, Scholl H, Fung J, Thomas PE, Alam J: Induction of pulmonary CYP1A1 by nicotine. . Xenobiotica. 1998 Sep;28(9):827-43.

5(0,0,0,5) Details
11849738 Wei C, Caccavale RJ, Weyand EH, Chen S, Iba MM: Induction of CYP1A1 and CYP1A2 expressions by prototypic and atypical inducers in the human lung. Cancer Lett. 2002 Apr 8;178(1):25-36.

4(0,0,0,4) Details
10460794 Iba MM, Fung J, Pak YW, Thomas PE, Fisher H, Sekowski A, Halladay AK, Wagner GC: Dose-dependent up-regulation of rat pulmonary, renal, and hepatic cytochrome P-450 (CYP) 1A expression by nicotine feeding. Drug Metab Dispos. 1999 Sep;27(9):977-82.


In the present study, we examined the dose-CYP1A1/2 induction response relationship and the tissue specificity of the induction by orally administered nicotine, which lacks the toxicity of the parenterally administered drug.
4(0,0,0,4) Details
9858665 Fung J, Thomas PE, Iba MM: Cytochrome P450 1A1 in rat peripheral blood lymphocytes: inducibility in vivo and bioactivation of benzo [a] pyrene in the Salmonella typhimurium mutagenicity assay in vitro. Mutat Res. 1999 Jan 2;438(1):1-12.

4(0,0,0,4) Details
14574441 Iba MM, Storch A, Ghosal A, Bennett S, Reuhl KR, Lowndes HE: Constitutive and inducible levels of CYP1A1 and CYP1A2 in rat cerebral cortex and cerebellum. Arch Toxicol. 2003 Oct;77(10):547-54. Epub 2003 Jul 11.

4(0,0,0,4) Details
11585058 Iba MM, Fung J: Pulmonary Cyp1A1 and CYP1A2 levels and activities in adult male and female offspring of rats exposed during gestation and lactation to 2,3,7, 8-tetrachlorodibenzo-p-dioxin. Biochem Pharmacol. 2001 Sep 1;62(5):617-26.

4(0,0,0,4) Details
10704945 Iba MM, Fung J, Cooper KR, Thomas PE, Wagner GC, Park Y: Effect of gestational and lactational 2,3,7, 8-tetrachlorodibenzo-p-dioxin exposure on the level and catalytic activities of hepatic microsomal CYP1A in prepubertal and adult rats. Biochem Pharmacol. 2000 May 1;59(9):1147-54.


We determined the inducibility, as well as the persistence of the induction, of hepatic microsomal CYP1A1 and CYP1A2 (by western blot analysis), and their catalytic activities (as measured by resorufin ether O-dealkylation) in prepubertal (25-day-old) and adult (120-day-old) offspring of timed-pregnant Sprague-Dawley rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
3(0,0,0,3) Details
10860547 Iba MM, Fung J, Giannone JV, Okey AB: Comparative induction of CYP1A1 expression by pyridine and its metabolites. Arch Biochem Biophys. 2000 Jun 15;378(2):299-310.

3(0,0,0,3) Details
10594335 Iba MM, Fung J: Induction of pulmonary cytochrome P4501A1: interactive effects of nicotine and mecamylamine. Eur J Pharmacol. 1999 Nov 3;383(3):399-403.


The effect of the nicotinic receptor antagonist mecamylamine on nicotine-mediated convulsions and induction of pulmonary cytochrome P4501A1 (CYP1A1) was examined in the rat.
3(0,0,0,3) Details
8287374 Iba MM, Bennett S, Storch A, Ghosal A, Thomas PE: Synergistic induction of rat microsomal CYP1A1 and CYP1A2 by acetone in combination with pyridine. Cancer Lett. 1993 Oct 15;74(1-2):69-74.

3(0,0,0,3) Details
6838636 Iba MM, Sikka HC: Induction of hepatic microsomal cytochrome P-448-mediated oxidases by 3,3'-dichlorobenzidine in the rat. Biochem Pharmacol. 1983 Mar 1;32(5):901-9.


Arylhydrocarbon hydroxylase activity was stimulated 5-fold by dichlorobenzidine pretreatment in comparison with a 12-fold stimulation following 3-methylcholanthrene pretreatment.
1(0,0,0,1) Details
10463385 Iba MM, Fung J, Thomas PE, Park Y: Constitutive and induced expression by pyridine and beta-naphthoflavone of rat CYP1A is sexually dimorphic. Arch Toxicol. 1999 Jun-Jul;73(4-5):208-16.


Adult male and female Sprague-Dawley rats were compared in terms of the constitutive levels and inducibility of CYP1A1 and CYP1A2 (CYP1A) in lung, kidney, and liver.
1(0,0,0,1) Details