Protein Information

Name tumor necrosis factor alpha
Synonyms Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
12574206 Sakamoto Y, Harada T, Horie S, Iba Y, Taniguchi F, Yoshida S, Iwabe T, Terakawa N: Tumor necrosis factor-alpha-induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factor-kappa B activation: gonadotropin-releasing hormone agonist treatment reduced IL-8 expression. J Clin Endocrinol Metab. 2003 Feb;88(2):730-5.

7(0,0,0,7) Details
15474070 Iba Y, Harada T, Horie S, Deura I, Iwabe T, Terakawa N: Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor alpha and interleukin-8 expression. Fertil Steril. 2004 Oct;82 Suppl 3:1036-42.

4(0,0,0,4) Details
8939900 Alevizopoulos A, Mermod N: Antagonistic regulation of a proline-rich transcription factor by transforming growth factor beta and tumor necrosis factor alpha. J Biol Chem. 1996 Nov 22;271(47):29672-81.

2(0,0,0,2) Details
17088948 He BP, Wang JJ, Zhang X, Wu Y, Wang M, Bay BH, Chang AY: Differential reactions of microglia to brain metastasis of lung cancer. . Mol Med. 2006 Jul-Aug;12(7-8):161-70.


In the region where the tumor mass was situated, only a few microglia expressed inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-alpha), indicating differential activation in those microglia.
1(0,0,0,1) Details
16429448 Fujioka M, Kanzaki S, Okano HJ, Masuda M, Ogawa K, Okano H: Proinflammatory cytokines expression in noise-induced damaged cochlea. . J Neurosci Res. 2006 Mar;83(4):575-83.


Tumor necrosis factor-alpha (TNF-alpha) was also slightly upregulated immediately after noise exposure.
1(0,0,0,1) Details
18601748 Iba T, Miyasho T: Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats. Crit Care. 2008;12(4):R86. Epub 2008 Jul 6.


The elevation of proinflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1, and IL-6 was significantly suppressed in the DA group.
1(0,0,0,1) Details
15699841 Iba T, Kidokoro A, Fukunaga M, Nagakari K, Shirahama A, Ida Y: Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model. Crit Care Med. 2005 Feb;33(2):368-72.


In another series, tumor necrosis factor, interleukin-6, alanine transaminase, and blood urea nitrogen levels were evaluated (n = 5).
1(0,0,0,1) Details
19670441 Byrnes KR, Stoica B, Riccio A, Pajoohesh-Ganji A, Loane DJ, Faden AI: Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents. Ann Neurol. 2009 Jul;66(1):63-74.


Administration of CHPG attenuated microglial-associated inflammatory responses in a dose-dependent fashion, including expression of ED1, Iba-1, Galectin-3, NADPH oxidase components, tumor necrosis factor-alpha, and inducible nitric oxide synthase.
1(0,0,0,1) Details
14501901 Iba T, Kidokoro A, Fukunaga M, Fuse S, Suda M: Antithrombin modulates the leukocyte-endothelial cell interaction in the staphylococcal enterotoxin B-challenged mouse. J Trauma. 2003 Sep;55(3):546-50.


A comparison of the intercellular adhesion molecule-1 (p < 0.05), soluble tumor necrosis factor-alpha receptor (p < 0.05), and interleukin-6 (p < 0.01) levels showed less increase in the treated mice.
1(0,0,0,1) Details
18496347 Hatashita S, Sekiguchi M, Kobayashi H, Konno S, Kikuchi S: Contralateral neuropathic pain and neuropathology in dorsal root ganglion and spinal cord following hemilateral nerve injury in rats. Spine (Phila Pa 1976). 2008 May 20;33(12):1344-51.


OBJECTIVES: We evaluated the longitudinal changes in contralateral mechanical allodynia, expression of tumor necrosis factor (TNF)-alpha and glial fibrillary acidic protein (GFAP)-positive satellite cells in the contralateral dorsal root ganglion (DRG), and expression of astrocytes and microglia in the contralateral spinal dorsal horn after hemilateral spinal nerve injury in rats.
1(0,0,0,1) Details
12426208 Kamihata H, Matsubara H, Nishiue T, Fujiyama S, Amano K, Iba O, Imada T, Iwasaka T: Improvement of collateral perfusion and regional function by implantation of peripheral blood mononuclear cells into ischemic hibernating myocardium. Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1804-10.


PB-MNCs and BM-MNCs contained similar levels of vascular endothelial growth factor and basic fibroblast growth factor, whereas contents of angiogenic cytokines (interleukin-1beta and tumor necrosis factor-alpha) were larger in PB-MNCs.
1(0,0,0,1) Details