Protein Information

Name fibronectin
Synonyms CIG; MSF; Cold insoluble globulin; FINC; FN; FN1; Fibronectin; Fibronectin 1…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
11108151 Matsubara H, Moriguchi Y, Mori Y, Masaki H, Tsutsumi Y, Shibasaki Y, Uchiyama-Tanaka Y, Fujiyama S, Koyama Y, Nose-Fujiyama A, Iba S, Tateishi E, Iwasaka T: Transactivation of EGF receptor induced by angiotensin II regulates fibronectin and TGF-beta gene expression via transcriptional and post-transcriptional mechanisms. Mol Cell Biochem. 2000 Sep;212(1-2):187-201.

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1326680 Iba T, Mills I, Sumpio BE: Intracellular cyclic AMP levels in endothelial cells subjected to cyclic strain in vitro. J Surg Res. 1992 Jun;52(6):625-30.


Human saphenous vein endothelial cells (EC) were grown to confluence in fibronectin-coated culture plates with flexible membrane bottoms and maintained in M-199 supplemented with substrates.
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11566906 Shibasaki Y, Matsubara H, Nozawa Y, Mori Y, Masaki H, Kosaki A, Tsutsumi Y, Uchiyama Y, Fujiyama S, Nose A, Iba O, Tateishi E, Hasegawa T, Horiuchi M, Nahmias C, Iwasaka T: Angiotensin II type 2 receptor inhibits epidermal growth factor receptor transactivation by increasing association of SHP-1 tyrosine phosphatase. Hypertension. 2001 Sep;38(3):367-72.


Induction of fibronectin gene containing an AP-1 responsive element in its 5'-flanking region was decreased by 37% after AT (2) stimulation, corresponding to the results of gel mobility assay with the AP-1 sequence of fibronectin as a probe.
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11737589 Uchiyama-Tanaka Y, Matsubara H, Nozawa Y, Murasawa S, Mori Y, Kosaki A, Maruyama K, Masaki H, Shibasaki Y, Fujiyama S, Nose A, Iba O, Hasagawa T, Tateishi E, Higashiyama S, Iwasaka T: Angiotensin II signaling and HB-EGF shedding via metalloproteinase in glomerular mesangial cells. Kidney Int. 2001 Dec;60(6):2153-63.


BACKGROUND: Angiotensin II (Ang II) has been implicated in the development of glomerulosclerosis by stimulating fibronectin (FN) synthesis.
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12584568 Shimizu Y, Yamamichi N, Saitoh K, Watanabe A, Ito T, Yamamichi-Nishina M, Mizutani M, Yahagi N, Suzuki T, Sasakawa C, Yasugi S, Ichinose M, Iba H: Kinetics of v-src-induced epithelial-mesenchymal transition in developing glandular stomach. Oncogene. 2003 Feb 13;22(6):884-93.


Continuous expression of v-src by, for example, Rous sarcoma virus (RSV) was required for the epithelial cells to acquire the ability to express type I collagen and fibronectin genes (mesenchymal markers), and finally to establish the epithelial-mesenchymal transition.
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