Protein Information

Name Mu opioid receptor
Synonyms MOR 1; MOR1; Mu opiate receptor; Mu opioid receptor; Mu type opioid receptor; OPRM; OPRM 1; OPRM1…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
10602337 Connor M, Borgland SL, Christie MJ: Continued morphine modulation of calcium channel currents in acutely isolated locus coeruleus neurons from morphine-dependent rats. Br J Pharmacol. 1999 Dec;128(7):1561-9.

In LC neurons maintained in 5 microM morphine, co-superfusion of naloxone (1 microM) or the mu-opioid receptor antagonist CTAP (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 1 microM) with morphine resulted in a significant increase in the amplitude of IBa.
31(0,1,1,1) Details
9824718 Soldo BL, Moises HC: mu-opioid receptor activation inhibits N- and P-type Ca2+ channel currents in magnocellular neurones of the rat supraoptic nucleus. J Physiol. 1998 Dec 15;513 ( Pt 3):787-804.

The mu-opioid receptor selective agonist, DAMGO, suppressed HVA IBa (in 64/71 neurones) in a naloxone-reversible and concentration-dependent manner (EC50 = 170 nM, Emax = 19.5 %).
83(1,1,1,3) Details
10323586 Connor M, Schuller A, Pintar JE, Christie MJ: Mu-opioid receptor modulation of calcium channel current in periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1. Br J Pharmacol. 1999 Apr;126(7):1553-8.

The actions of opioid receptor agonists on the calcium channel currents (IBa) of acutely dissociated periaqueductal grey (PAG) neurons from C57B16/J mice and mutant mice lacking the first exon of the mu-opioid receptor (MOR-1) were examined using whole cell patch clamp techniques.
32(0,1,1,2) Details
9463438 Adams DJ, Trequattrini C: Opioid receptor-mediated inhibition of omega-conotoxin GVIA-sensitive calcium channel currents in rat intracardiac neurons. J Neurophysiol. 1998 Feb;79(2):753-62.

Half-maximal inhibition of Ba2+ current (IBa) amplitude was obtained with 270 nM Met-enkephalin or Leu-enkephalin.
Taken together, these data suggest that enkephalin-induced inhibition of Ca2+ channels in rat intracardiac neurons is mediated primarily by the mu-opioid receptor type.
2(0,0,0,2) Details