Protein Information

Name monocyte chemoattractant protein 1
Synonyms CCL 2; MCAF; CCL2; GDCF 2; GDCF 2 HC11; GDCF2; HC11; HSMCR30…

Compound Information

Name IBA
CAS

Reference List

PubMed Abstract RScore(About this table)
12944523 Babcock AA, Kuziel WA, Rivest S, Owens T: Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. J Neurosci. 2003 Aug 27;23(21):7922-30.


A broad spectrum of chemokines [RANTES/CCL5, monocyte chemoattractant protein (MCP)-1/CCL2, interferon gamma inducible protein (IP)-10/CXCL10, macrophage inflammatory protein (MIP)-1alpha/CCL3, MIP-1beta/CCL4, and MIP-2/CXCL2] was induced at this time.
2(0,0,0,2) Details
18165263 Borda JT, Alvarez X, Mohan M, Ratterree MS, Phillippi-Falkenstein K, Lackner AA, Bunnell BA: Clinical and immunopathologic alterations in rhesus macaques affected with globoid cell leukodystrophy. Am J Pathol. 2008 Jan;172(1):98-111. Epub 2007 Dec 28.


Cytokine mRNA levels revealed markedly increased gene expression of CCL2 in the brain of affected macaques.
2(0,0,0,2) Details
19410369 Hathway GJ, Vega-Avelaira D, Moss A, Ingram R, Fitzgerald M: Brief, low frequency stimulation of rat peripheral C-fibres evokes prolonged microglial-induced central sensitization in adults but not in neonates. Pain. 2009 Jul;144(1-2):110-8. Epub 2009 May 1.


C-fibre evoked sensitization was accompanied by significant microglial activation, shown by increased Iba-1 immunoreactivity throughout the dorsal horn at 24 and 48 h and significant upregulation of markers of microglial activation: IL-6 and Mcp-1 at 3h and Mmp3, CSF-1 and CD163 at 24 and 48 h.
1(0,0,0,1) Details
18190912 He J, Crews FT: Increased MCP-1 and microglia in various regions of the human alcoholic brain. Exp Neurol. 2008 Apr;210(2):349-58. Epub 2007 Dec 3.


In the current study, human postmortem brains from moderate drinking controls and alcoholics obtained from the New South Wales Tissue Resource Center were used to study the cytokine, monocyte chemoattractant protein 1 (MCP-1,CCL2) and microglia markers in various brain regions.
1(0,0,0,1) Details
17823975 Ji KA, Yang MS, Jeong HK, Min KJ, Kang SH, Jou I, Joe EH: Resident microglia die and infiltrated neutrophils and monocytes become major inflammatory cells in lipopolysaccharide-injected brain. Glia. 2007 Nov 15;55(15):1577-88.


MPO (+) neutrophils expressed inducible nitric oxide synthase, interleukin-1beta, cyclooxygenase-2, and monocyte chemoattractant protein-1, but died within 18 h.
1(0,0,0,1) Details