Protein Information

Name sodium channel (protein family or complex)
Synonyms Sodium channel

Compound Information

Name fenfluthrin
CAS

Reference List

PubMed Abstract RScore(About this table)
2449265 Ruigt GS, Neyt HC, Van der Zalm JM, Van den Bercken J: Increase of sodium current after pyrethroid insecticides in mouse neuroblastoma cells. Brain Res. 1987 Dec 29;437(2):309-22.

The effects of 4 different pyrethroid insecticides on sodium channel gating in internally perfused, cultured mouse neuroblastoma cells (N1E-115) were studied using the suction pipette, voltage clamp technique.
The rate of decay of the slow tail current strongly depended on pyrethroid structure and increased in the order deltamethrin, cyphenothrin, fenfluthrin and phenothrin.
1(0,0,0,1) Details
17991435 Usherwood PN, Davies TG, Mellor IR, O'Reilly AO, Peng F, Vais H, Khambay BP, Field LM, Williamson MS: Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT. FEBS Lett. 2007 Nov 27;581(28):5485-92. Epub 2007 Nov 6.

Substitutions L914I, M918T, L925I, T929I and C933A decreased deltamethrin potency, M918T, L925I and T929I decreased permethrin potency and T929I, L925I and I936V decreased fenfluthrin potency.
2(0,0,0,2) Details