| Name | cytochrome P450 (protein family or complex) |
|---|---|
| Synonyms | cytochrome P450; cytochrome P 450; CYP450; CYP 450 |
| Name | ancymidol |
|---|---|
| CAS | α-cyclopropyl-α-(4-methoxyphenyl)-5-pyrimidinemethanol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11556809 | Ralston L, Kwon ST, Schoenbeck M, Ralston J, Schenk DJ, Coates RM, Chappell J: Cloning, heterologous expression, and functional characterization of 5-epi-aristolochene-1,3-dihydroxylase from tobacco (Nicotiana tabacum). Arch Biochem Biophys. 2001 Sep 15;393(2):222-35. In extending these observations, we developed an in vivo assay for 5-epi-aristolochene hydroxylase activity and used it to demonstrate a dose-dependent inhibition of activity by ancymidol and ketoconazole, two well characterized inhibitors of cytochrome P450 enzymes. |
82(1,1,1,2) | Details |
| 7702568 | Morandini P, Offer J, Traynor D, Nayler O, Neuhaus D, Taylor GW, Kay RR: The proximal pathway of metabolism of the chlorinated signal molecule differentiation-inducing factor-1 (DIF-1) in the cellular slime mould Dictyostelium. Biochem J. 1995 Mar 15;306 ( Pt 3):735-43. DIF-3 hydroxylase has many of the properties of a cytochrome P-450. One of the inhibitors of DIF-3 hydroxylase, ancymidol (IC50 67 nM) is likely to be particularly suitable for probing the function of DIF metabolism during development. |
2(0,0,0,2) | Details |
| 15012200 | Rademacher W: GROWTH RETARDANTS: Effects on Biosynthesis and Other Metabolic Pathways. Annu Rev Plant Physiol Plant Mol Biol. 2000 Jun;51:501-531. To date, four different types of such inhibitors are known: (a) Onium compounds, such as chlormequat mepiquat chlorphonium, and AMO-1618, which block the cyclases copalyl- synthase and ent-kaurene synthase involved in the early steps of GA metabolism. (b) Compounds with an N-containing heterocycle, e.g. ancymidol, flurprimidol, tetcyclacis, paclobutrazol, uniconazole-P, and inabenfide. These retardants block cytochrome P450-dependent monooxygenases, thereby inhibiting oxidation of ent-kaurene into ent-kaurenoic acid. (c) Structural mimics of which is the co-substrate of dioxygenases that catalyze late steps of GA formation. |
1(0,0,0,1) | Details |