Protein Information

Name SSI2
Synonyms CIS 2; CIS2; Cish2; Cytokine inducible SH2 protein 2; SOCS 2; SOCS2; SSI 2; SSI2…

Compound Information

Name jasmonic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
14601670 Kachroo P, Kachroo A, Lapchyk L, Hildebrand D, Klessig DF: Restoration of defective cross talk in ssi2 mutants: role of salicylic acid, jasmonic acid, and fatty acids in SSI2-mediated signaling. Mol Plant Microbe Interact. 2003 Nov;16(11):1022-9.
32(0,1,1,2) Details
17072561 Kachroo A, Shanklin J, Whittle E, Lapchyk L, Hildebrand D, Kachroo P: The Arabidopsis stearoyl-acyl carrier protein-desaturase family and the contribution of leaf isoforms to oleic acid synthesis. Plant Mol Biol. 2007 Jan;63(2):257-71. Epub 2006 Oct 28.

In plants, changes in the levels of oleic acid (18:1), a major monounsaturated fatty acid (FA), results in the alteration of salicylic acid (SA)- and jasmonic acid (JA)-mediated defense responses.
In addition to SSI2, the Arabidopsis genome encodes six S-ACP-DES-like enzymes, the native expression levels of which are unable to compensate for a loss-of-function mutation in ssi2.
2(0,0,0,2) Details
11481500 Kachroo P, Shanklin J, Shah J, Whittle EJ, Klessig DF: A fatty acid desaturase modulates the activation of defense signaling pathways in plants. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9448-53.

In contrast, a subset of defense responses regulated by the jasmonic acid (JA) signaling pathway, including expression of the defensin gene PDF1.2 and resistance to Botrytis cinerea, is impaired in ssi2 plants.
With the use of a map-based approach, the SSI2 gene was cloned and shown to encode a stearoyl-ACP desaturase (S-ACP DES).
1(0,0,0,1) Details
15828688 Nandi A, Moeder W, Kachroo P, Klessig DF, Shah J: Arabidopsis ssi2-conferred susceptibility to Botrytis cinerea is dependent on EDS5 and PAD4. Mol Plant Microbe Interact. 2005 Apr;18(4):363-70.

Our results suggest that interaction between an SSI2-dependent factor or factors and an EDS5- and PAD4-dependent mechanism or mechanisms modulates defense to B. cinerea.
The altered basal resistance to these pathogens in the ssi2 mutant plant is accompanied by the constitutive accumulation of elevated salicylic acid (SA) level and expression of the pathogenesis-related 1 (PR1) gene, the inability of jasmonic acid (JA) to activate expression of the defensin gene, PDF1.2, and the spontaneous death of cells.
1(0,0,0,1) Details
15044700 Kachroo A, Venugopal SC, Lapchyk L, Falcone D, Hildebrand D, Kachroo P: Oleic acid levels regulated by glycerolipid metabolism modulate defense gene expression in Arabidopsis. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5152-7. Epub 2004 Mar 25.

Glycerol application also lowered the 18:1 content in SSI2 plants and converted these into ssi2-mimics.
Here we show that a mutation in G3P dehydrogenase restores both salicylic acid- and jasmonic acid-mediated phenotypes of ssi2 plants.
1(0,0,0,1) Details
14615603 Kachroo A, Lapchyk L, Fukushige H, Hildebrand D, Klessig D, Kachroo P: Plastidial fatty acid signaling modulates salicylic acid- and jasmonic acid-mediated defense pathways in the Arabidopsis ssi2 mutant. Plant Cell. 2003 Dec;15(12):2952-65. Epub 2003 Nov 13.

Our conclusion that FA signaling in plastids plays an essential role in the regulation of SSI2-mediated defense signaling is further substantiated by the fact that overexpression of the N-terminal-deleted SSI2, which lacks the putative plastid-localizing transit peptide, is unable to rescue ssi2-triggered phenotypes, as opposed to overexpression of the full-length protein.
1(0,0,0,1) Details
14507997 Nandi A, Krothapalli K, Buseman CM, Li M, Welti R, Enyedi A, Shah J: Arabidopsis sfd mutants affect plastidic lipid composition and suppress dwarfing, cell death, and the enhanced disease resistance phenotypes resulting from the deficiency of a fatty acid desaturase. Plant Cell. 2003 Oct;15(10):2383-98. Epub 2003 Sep 24.

A loss-of-function mutation in the Arabidopsis SSI2/FAB2 gene, which encodes a plastidic stearoyl-acyl-carrier protein desaturase, has pleiotropic effects.
In parallel, jasmonic acid-regulated signaling is compromised in the ssi2 mutant.
1(0,0,0,1) Details