| Name | NPR1 |
|---|---|
| Synonyms | A/Guanylate cyclase A; ANP A; ANPRA; ANPa; Atrial natriuretic peptide A type receptor; Atrial natriuretic peptide receptor A precursor (ANP A) (ANPRA) (GC A) (Guanylate cyclase); Atrionatriuretic peptide receptor A; GC A… |
| Name | jasmonic acid |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 11169191 | Yoshioka K, Nakashita H, Klessig DF, Yamaguchi I: Probenazole induces systemic acquired resistance in Arabidopsis with a novel type of action. Plant J. 2001 Jan;25(2):149-57. The role of several defense signaling hormones, such as SA, ethylene and jasmonic acid (JA), in activating resistance following PBZ or BIT treatment was analyzed using NahG transgenic plants and etr1-1 and coi1-1 mutant plants, respectively. In addition, the involvement of NPR1, a key component in the SA signaling pathway leading to defense responses, was assessed. |
3(0,0,0,3) | Details |
| 14507997 | Nandi A, Krothapalli K, Buseman CM, Li M, Welti R, Enyedi A, Shah J: Arabidopsis sfd mutants affect plastidic lipid composition and suppress dwarfing, cell death, and the enhanced disease resistance phenotypes resulting from the deficiency of a fatty acid desaturase. Plant Cell. 2003 Oct;15(10):2383-98. Epub 2003 Sep 24. The ssi2 mutant plant is dwarf, spontaneously develops lesions containing dead cells, accumulates increased (SA) levels, and constitutively expresses SA-mediated, NPR1-dependent and -independent defense responses. In parallel, jasmonic acid-regulated signaling is compromised in the ssi2 mutant. |
3(0,0,0,3) | Details |
| 11090217 | Clarke JD, Volko SM, Ledford H, Ausubel FM, Dong X: Roles of jasmonic acid, and ethylene in cpr-induced resistance in arabidopsis. Plant Cell. 2000 Nov;12(11):2175-90. These data indicate the existence of an SA-mediated, NPR1-independent resistance response. |
3(0,0,0,3) | Details |
| 17981874 | Bonaventure G, Gfeller A, Rodriguez VM, Armand F, Farmer EE: The fou2 gain-of-function allele and the wild-type allele of Two Pore Channel 1 contribute to different extents or by different mechanisms to defense gene expression in Arabidopsis. Plant Cell Physiol. 2007 Dec;48(12):1775-89. Epub 2007 Nov 2. This mutant genetically implicates cation fluxes in the control of the positive feedback loop whereby jasmonic acid (JA) stimulates its own synthesis. In addition, generation of fou2 aba1-5, fou2 etr1-1 and fou2 npr1-1 double mutants showed that the fou2 phenotype was only weakly affected by ABA levels and unaffected by mutations in NPR1 and ETR1. |
1(0,0,0,1) | Details |
| 15242170 | Berrocal-Lobo M, Molina A: Ethylene response factor 1 mediates Arabidopsis resistance to the soilborne fungus Fusarium oxysporum. Mol Plant Microbe Interact. 2004 Jul;17(7):763-70. Expression of ERF1 was upregulated after inoculation with F. oxysporum f. sp. conglutinans, and this response was blocked in ein2-5 and coi1-1 mutants, impaired in the ethylene (ET) and jasmonic acid (JA) signal pathways, respectively, which further indicates that ERF1 is a downstream component of ET and JA defense responses. This analysis revealed that Arabidopsis resistance to F. oxysporum requires the ET, JA, and SA signaling pathways and the NPR1 gene, although it is independent of the PAD4 and EDS1 functions. |
1(0,0,0,1) | Details |
| 15337097 | Dong X: NPR1, all things considered. Curr Opin Plant Biol. 2004 Oct;7(5):547-52. Recent work has shown that the Arabidopsis NPR1 protein not only plays an essential role in (SA)-mediated systemic acquired resistance and rhizobacterium-triggered induced systemic resistance, but also is involved in crosstalk inhibition of jasmonic acid (JA)-mediated defense responses. |
3(0,0,0,3) | Details |
| 11481500 | Kachroo P, Shanklin J, Shah J, Whittle EJ, Klessig DF: A fatty acid desaturase modulates the activation of defense signaling pathways in plants. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9448-53. A critical positive regulator of the SA signaling pathway in Arabidopsis is encoded by the NPR1 gene. In contrast, a subset of defense responses regulated by the jasmonic acid (JA) signaling pathway, including expression of the defensin gene PDF1.2 and resistance to Botrytis cinerea, is impaired in ssi2 plants. |
3(0,0,0,3) | Details |
| 16039901 | Lorenzo O, Solano R: Molecular players regulating the jasmonate signalling network. Curr Opin Plant Biol. 2005 Oct;8(5):532-40. Genes that are involved in the regulation of protein stability through the ubiquitin-proteasome pathway (COI1, AXR1 and SGT1b), signalling proteins (MPK4) and transcription factors (AtMYC2, ERF1, NPR1 and WRKY70) form a regulatory network that allows the plant to fine-tune specific responses to different stimuli. |
1(0,0,0,1) | Details |
| 17397508 | Ndamukong I, Abdallat AA, Thurow C, Fode B, Zander M, Weigel R, Gatz C: SA-inducible Arabidopsis glutaredoxin interacts with TGA factors and suppresses JA-responsive PDF1.2 transcription. Plant J. 2007 Apr;50(1):128-39. Moreover, it antagonizes gene induction by the stress signaling molecule jasmonic acid (JA). TGA factors interact with NPR1, a central regulator of many SA-induced defense responses including SA/JA antagonism. |
3(0,0,0,3) | Details |
| 19213807 | Bergougnoux V, Hlavackova V, Plotzova R, Novak O, Fellner M: The 7B-1 mutation in tomato (Solanum lycopersicum L.) confers a blue light-specific lower sensitivity to coronatine, a toxin produced by Pseudomonas syringae pv. tomato. J Exp Bot. 2009;60(4):1219-30. Epub 2009 Feb 12. Treatment of WT and 7B-1 plants with COR induced a strong accumulation of (SA), jasmonic acid (JA), and abscisic acid (ABA) in hypocotyls. Based on the cross-talk between SA- and JA-signalling pathways, expression analysis of NPR1 and COI1 genes, respectively involved in these pathways, was investigated in COR-stressed plants. |
3(0,0,0,3) | Details |
| 10890883 | van Wees SC, de Swart EA, van Pelt JA, van Loon LC, Pieterse CM: Enhancement of induced disease resistance by simultaneous activation of - and jasmonate-dependent defense pathways in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8711-6. SAR and ISR both require the key regulatory protein NPR1. The plant-signaling molecules (SA) and jasmonic acid (JA) play an important role in induced disease resistance pathways. |
2(0,0,0,2) | Details |
| 16478936 | Liechti R, Gfeller A, Farmer EE: Jasmonate signaling pathway. Sci STKE. 2006 Feb 14;2006(322):cm2. As progress in characterizing several new mutants (some of which are hypersensitive to jasmonic acid) augments our understanding of jasmonate signaling, the Connections Map will be updated to include this new information. In Arabidopsis, NONEXPRESSOR OF PR GENES (NPR1) mediates part of this interaction, with another layer of control provided further downstream by the mitogen-activated protein kinase (MAPK) homolog MPK4. |
1(0,0,0,1) | Details |
| 11850411 | Brodersen P, Petersen M, Pike HM, Olszak B, Skov S, Odum N, Jorgensen LB, Brown RE, Mundy J: Knockout of Arabidopsis accelerated-cell-death11 encoding a transfer protein causes activation of programmed cell death and defense. Genes Dev. 2002 Feb 15;16(4):490-502. The PCD and defense pathways activated in acd11 are (SA) dependent, but do not require intact jasmonic acid or ethylene signaling pathways. |
0(0,0,0,0) | Details |
| 19121119 | Sultana F, Hossain MM, Kubota M, Hyakumachi M: Induction of systemic resistance in Arabidopsis thaliana in response to a culture filtrate from a plant growth-promoting fungus, Phoma sp. Plant Biol. 2009 Jan;11(1):97-104. Pathway-specific mutant plants, such as jar1 (jasmonic acid insensitive) and ein2 (ethylene insensitive), and transgenic NahG plants (impaired in signalling) were protected after application of the CF, demonstrating that these pathways are dispensable (at least individually) in CF-mediated resistance. |
0(0,0,0,0) | Details |
| 16435264 | Beckers GJ, Spoel SH: Fine-Tuning Plant Defence Signalling: versus Jasmonate. Plant Biol. 2006 Jan;8(1):1-10. The signalling molecules (SA) and jasmonic acid (JA) play important roles in this network. SA-activated NPR1 localizes to the nucleus where it interacts with TGA transcription factors to induce the expression of a large set of pathogenesis-related proteins that contribute to the enhanced state of resistance. |
2(0,0,0,2) | Details |
| 16307367 | Blanco F, Garreton V, Frey N, Dominguez C, Perez-Acle T, Van der Straeten D, Jordana X, Holuigue L: Identification of NPR1-dependent and independent genes early induced by treatment in Arabidopsis. Plant Mol Biol. 2005 Dec;59(6):927-44. |
2(0,0,0,2) | Details |
| 15842626 | Prithiviraj B, Bais HP, Jha AK, Vivanco JM: Staphylococcus aureus pathogenicity on Arabidopsis thaliana is mediated either by a direct effect of on the pathogen or by SA-dependent, NPR1-independent host responses. Plant J. 2005 May;42(3):417-32. Further, using Arabidopsis plants altered in defense responses such as the transgenic lines NahG [defective in (SA) accumulation], and 35S-LOX2- (defective in jasmonic acid production and hyper-accumulator of SA), and mutants ics1 (depleted in SA accumulation), and npr1-1 (non-expressor of pathogenesis-related protein) we show that resistance of Arabidopsis to typical plant pathogens and the animal pathogen S. aureus is conserved and is mediated by SA. |
2(0,0,0,2) | Details |
| 15923348 | Coego A, Ramirez V, Gil MJ, Flors V, Mauch-Mani B, Vera P: An Arabidopsis homeodomain transcription factor, OVEREXPRESSOR OF CATIONIC PEROXIDASE 3, mediates resistance to infection by necrotrophic pathogens. Plant Cell. 2005 Jul;17(7):2123-37. Epub 2005 May 27. These studies revealed that the resistance signaling to necrotrophic infection in ocp3 is fully dependent on appropriate perception of jasmonic acid through COI1 and does not require SA or ethylene perception through NPR1 or EIN2, respectively. |
0(0,0,0,0) | Details |
| 16415067 | Yaeno T, Saito B, Katsuki T, Iba K: Ozone-induced expression of the Arabidopsis FAD7 gene requires but not NPR1 and SID2. Plant Cell Physiol. 2006 Mar;47(3):355-62. Epub 2006 Jan 13. This induction was reduced in (SA)-deficient NahG plants expressing SA hydroxylase, but was unaffected in etr1 and jar1 mutants, which are insensitive to ethylene and jasmonic acid (JA), respectively. |
0(0,0,0,0) | Details |
| 11439131 | Yoshioka K, Kachroo P, Tsui F, Sharma SB, Shah J, Klessig DF: Environmentally sensitive, SA-dependent defense responses in the cpr22 mutant of Arabidopsis. Plant J. 2001 May;26(4):447-59. However, the SA signal transducer NPR1 was required only for constitutive PR-1 expression. |
2(0,0,0,2) | Details |
| 16941900 | Johansson A, Staal J, Dixelius C: Early responses in the Arabidopsis-Verticillium longisporum pathosystem are dependent on NDR1, JA- and ET-associated signals via cytosolic NPR1 and RFO1. Mol Plant Microbe Interact. 2006 Sep;19(9):958-69. Analysis of mutants impaired in known pathogen response pathways revealed an enhanced susceptibility in ein2-1, ein4-1, ein6-1, esa1-1, and pad1-1, but not in other jasmonic acid (JA)-, ethylene (ET)-, or camalexin-deficient mutants, suggesting that V. longisporum resistance is regulated via a hitherto unknown JA- and ET-associated pathway. |
2(0,0,0,2) | Details |
| 18397206 | Meur G, Budatha M, Srinivasan T, Rajesh Kumar KR, Dutta Gupta A, Kirti PB: Constitutive expression of Arabidopsis NPR1 confers enhanced resistance to the early instars of Spodoptera litura in transgenic tobacco. Physiol Plant. 2008 Aug;133(4):765-75. Epub 2008 Apr 7. AtNPR1 also modulates SA-induced suppression of jasmonic acid-responsive gene expression, and npr1 mutants manifest enhanced herbivore resistance. |
2(0,0,0,2) | Details |
| 12615947 | Spoel SH, Koornneef A, Claessens SM, Korzelius JP, Van Pelt JA, Mueller MJ, Buchala AJ, Metraux JP, Brown R, Kazan K, Van Loon LC, Dong X, Pieterse CM: NPR1 modulates cross-talk between - and jasmonate-dependent defense pathways through a novel function in the cytosol. Plant Cell. 2003 Mar;15(3):760-70. Plant defenses against pathogens and insects are regulated differentially by cross-communicating signal transduction pathways in which (SA) and jasmonic acid (JA) play key roles. |
2(0,0,0,2) | Details |
| 9927638 | Shah J, Kachroo P, Klessig DF: The Arabidopsis ssi1 mutation restores pathogenesis-related gene expression in npr1 plants and renders defensin gene expression dependent. Plant Cell. 1999 Feb;11(2):191-206. The Arabidopsis NPR1 gene was previously shown to be required for the (SA)- and benzothiadiazole (BTH)-induced expression of pathogenesis-related (PR) genes and systemic acquired resistance. Interestingly, expression of PDF1.2, which previously has been shown to be SA independent but jasmonic acid and ethylene dependent, was also suppressed in ssi1 npr1-5 plants by the nahG gene. |
2(0,0,0,2) | Details |
| 19018998 | Cuzick A, Lee S, Gezan S, Hammond-Kosack KE: NPR1 and EDS11 contribute to host resistance against Fusarium culmorum in Arabidopsis buds and flowers. Mol Plant Pathol. 2008 Sep;9(5):697-704. Here we assessed the effect of seven mutants and one transgenic overexpression line, residing in either the (SA), jasmonic acid (JA) or ethylene (ET) defence signalling pathways, on the outcome of the Fusarium-Arabidopsis floral interaction. |
2(0,0,0,2) | Details |
| 19413686 | Van der Ent S, Van Hulten M, Pozo MJ, Czechowski T, Udvardi MK, Pieterse CM, Ton J: Priming of plant innate immunity by rhizobacteria and beta-aminobutyric acid: differences and similarities in regulation. New Phytol. 2009;183(2):419-31. Epub 2009 Apr 29. Conversely, induced resistance by WCS417r and beta-aminobutyric acid against the bacterial pathogen Pseudomonas syringae are controlled by distinct NPR1-dependent signalling pathways. |
2(0,0,0,2) | Details |
| 19304739 | Kawamura Y, Takenaka S, Hase S, Kubota M, Ichinose Y, Kanayama Y, Nakaho K, Klessig DF, Takahashi H: Enhanced defense responses in Arabidopsis induced by the cell wall protein fractions from Pythium oligandrum require SGT1, RAR1, NPR1 and JAR1. Plant Cell Physiol. 2009 May;50(5):924-34. Epub 2009 Mar 20. In tomato plants treated with CWP, jasmonic acid (JA)- and ethylene (ET)-dependent signaling pathways are activated, and resistance to Ralstonia solanaceraum is enhanced. |
2(0,0,0,2) | Details |
| 17158583 | Ahn IP, Kim S, Lee YH, Suh SC: -induced priming is dependent on peroxide and the NPR1 gene in Arabidopsis. Plant Physiol. 2007 Feb;143(2):838-48. Epub 2006 Dec 8. treatment and subsequent pathogen invasion triggered peroxide accumulation, callose induction, and PR1/PAL1 transcription activation in Arabidopsis mutants insensitive to jasmonic acid (jar1), ethylene (etr1), or abscisic acid (abi3-3), but not in plants expressing bacterial NahG and lacking regulation of SAR (npr1 [nonexpressor of PR genes 1]). |
2(0,0,0,2) | Details |
| 18218973 | Fabro G, Di Rienzo JA, Voigt CA, Savchenko T, Dehesh K, Somerville S, Alvarez ME: Genome-wide expression profiling Arabidopsis at the stage of Golovinomyces cichoracearum haustorium formation. Plant Physiol. 2008 Mar;146(3):1421-39. Epub 2008 Jan 24. At this time, the endogenous levels of (SA) and jasmonic acid (JA) were found to be enhanced. The responses of wild-type, npr1-1, and jar1-1 plants were used to categorize the sensitivity of gene expression changes to NPR1 and JAR1, which are components of the SA and JA signaling pathways, respectively. |
2(0,0,0,2) | Details |
| 17850230 | Rayapuram C, Baldwin IT: Increased SA in NPR1-silenced plants antagonizes JA and JA-dependent direct and indirect defenses in herbivore-attacked Nicotiana attenuata in nature. Plant J. 2007 Nov;52(4):700-15. Epub 2007 Sep 10. The phytohormone jasmonic acid (JA) is known to mediate herbivore resistance, while (SA) and non-expressor of PR-1 (NPR1) mediate pathogen resistance in many plants. |
86(1,1,1,6) | Details |
| 17510065 | Mao P, Duan M, Wei C, Li Y: WRKY62 transcription factor acts downstream of cytosolic NPR1 and negatively regulates jasmonate-responsive gene expression. Plant Cell Physiol. 2007 Jun;48(6):833-42. Epub 2007 May 16. Cytosolic NPR1 has been shown to be essential for the (SA)-mediated suppression of jasmonic acid (JA)-responsive gene expression. |
85(1,1,1,5) | Details |
| 14742872 | Li J, Brader G, Palva ET: The WRKY70 transcription factor: a node of convergence for jasmonate-mediated and -mediated signals in plant defense. Plant Cell. 2004 Feb;16(2):319-31. Epub 2004 Jan 23. Cross talk between (SA)- and jasmonic acid (JA)-dependent defense signaling has been well documented in plants, but how this cross talk is executed and the components involved remain to be elucidated. The early induction of WRKY70 by SA is NPR1-independent, but functional NPR1 is required for full-scale induction. |
2(0,0,0,2) | Details |
| 16623907 | Li J, Brader G, Kariola T, Palva ET: WRKY70 modulates the selection of signaling pathways in plant defense. Plant J. 2006 May;46(3):477-91. We show that this WRKY70-controlled suppression of JA-signaling is partly executed by NPR1. Our studies have identified WRKY70 as a node of convergence for integrating (SA)- and jasmonic acid (JA)-mediated signaling events during plant response to bacterial pathogens. |
1(0,0,0,1) | Details |
| 16325410 | Schenk PM, Kazan K, Rusu AG, Manners JM, Maclean DJ: The SEN1 gene of Arabidopsis is regulated by signals that link plant defence responses and senescence. Plant Physiol Biochem. 2005 Oct-Nov;43(10-11):997-1005. Epub 2005 Nov 7. Expression analysis of SEN1 in a number of defence signalling mutants indicated that activation of this gene by pathogen occurs predominantly via the salicylic and jasmonic acid signalling pathways, involving the functions of EDS5, NPR1 and JAR1. |
81(1,1,1,1) | Details |
| 16377744 | Mur LA, Kenton P, Atzorn R, Miersch O, Wasternack C: The outcomes of concentration-specific interactions between and jasmonate signaling include synergy, antagonism, and oxidative stress leading to cell death. Plant Physiol. 2006 Jan;140(1):249-62. Epub 2005 Dec 23. (SA) has been proposed to antagonize jasmonic acid (JA) biosynthesis and signaling. Synergic effects on gene expression and plant stress were NPR1- and COI1-dependent, SA- and JA-signaling components, respectively. |
1(0,0,0,1) | Details |
| 10886772 | McDowell JM, Cuzick A, Can C, Beynon J, Dangl JL, Holub EB: Downy mildew (Peronospora parasitica) resistance genes in Arabidopsis vary in functional requirements for NDR1, EDS1, NPR1 and accumulation. Plant J. 2000 Jun;22(6):523-9. RPP7 resistance was also not compromised by mutations in EIN2, JAR1 or COI1 which affect ethylene or jasmonic acid signaling. |
1(0,0,0,1) | Details |
| 18842596 | Stein E, Molitor A, Kogel KH, Waller F: Systemic resistance in Arabidopsis conferred by the mycorrhizal fungus Piriformospora indica requires jasmonic acid signaling and the cytoplasmic function of NPR1. Plant Cell Physiol. 2008 Nov;49(11):1747-51. Epub 2008 Oct 7. |
81(1,1,1,1) | Details |
| 15773856 | Xiao S, Calis O, Patrick E, Zhang G, Charoenwattana P, Muskett P, Parker JE, Turner JG: The atypical resistance gene, RPW8, recruits components of basal defence for powdery mildew resistance in Arabidopsis. Plant J. 2005 Apr;42(1):95-110. We show that RPW8.1 and RPW8.2 recruit, in addition to and EDS1, the other NB-LRR gene-signalling components PAD4, EDS5, NPR1 and SGT1b for activation of powdery mildew resistance and HR. In contrast, NDR1, RAR1 and PBS3 that are required for function of certain NB-LRR R genes, and COI1 and EIN2 that operate, respectively, in the jasmonic acid and ethylene signalling pathways, do not contribute to RPW8.1 and RPW8.2-mediated resistance. |
1(0,0,0,1) | Details |
| 19825557 | Zhang Z, Lenk A, Andersson MX, Gjetting T, Pedersen C, Nielsen ME, Newman MA, Hou BH, Somerville SC, Thordal-Christensen H: A lesion-mimic syntaxin double mutant in Arabidopsis reveals novel complexity of pathogen defense signaling. Mol Plant. 2008 May;1(3):510-27. Epub 2008 Apr 15. Analyses of quadruple mutants suggest that EDS5 and SID2 confer separate SA-independent signaling functions, and that FMO1 and ALD1 mediate SA-independent signals that are NPR1-dependent. |
1(0,0,0,1) | Details |
| 14558686 | Iavicoli A, Boutet E, Buchala A, Metraux JP: Induced systemic resistance in Arabidopsis thaliana in response to root inoculation with Pseudomonas fluorescens CHA0. Mol Plant Microbe Interact. 2003 Oct;16(10):851-8. CHA0r-mediated ISR was also tested in various Arabidopsis mutants and transgenic plants: NahG (transgenic line degrading [SA]), sid2-1 (nonproducing SA), npr1-1 (non-expressing NPR1 protein), jar1-1 (insensitive to jasmonic acid and methyl jasmonic acid), ein2-1 (insensitive to ethylene), etr1-1 (insensitive to ethylene), eir1-1 (insensitive to ethylene in roots), and pad2-1 (phytoalexin deficient). |
37(0,1,2,2) | Details |
| 16176083 | Zhang HZ, Cai XZ: [Nonexpressor of pathogenesis-related genes 1 (NPR1): a key node of plant disease resistance signalling network]. Sheng Wu Gong Cheng Xue Bao. 2005 Jul;21(4):511-5. As a cross-talk point of a variety of defense signaling pathways, probably through direct or indirect interacting with some WRKY TFs and a NPR1-like protein NPR4, NPR1 is essential in balancing - and jasmonic acid- dependent signal transduction pathways, which is achieved through an unknown mechanism in the cytosol. |
35(0,1,1,5) | Details |
| 12848825 | Ferrari S, Plotnikova JM, De Lorenzo G, Ausubel FM: Arabidopsis local resistance to Botrytis cinerea involves and camalexin and requires EDS4 and PAD2, but not SID2, EDS5 or PAD4. Plant J. 2003 Jul;35(2):193-205. Although npr1 mutant leaves were normally susceptible to B. cinerea infection, a double ein2 npr1 mutant was significantly more susceptible than ein2 plants, and exogenous application of SA decreased B. cinerea lesion size through an NPR1-dependent mechanism that could be mimicked by the cpr1 mutation. |
1(0,0,0,1) | Details |
| 19773385 | Yoshimoto K, Jikumaru Y, Kamiya Y, Kusano M, Consonni C, Panstruga R, Ohsumi Y, Shirasu K: Autophagy negatively regulates cell death by controlling NPR1-dependent signaling during senescence and the innate immune response in Arabidopsis. Plant Cell. 2009 Sep;21(9):2914-27. Epub 2009 Sep 22. The atg mutant phenotypes of accelerated PCD in senescence and immunity are SA signaling dependent but do not require intact jasmonic acid or ethylene signaling pathways. |
1(0,0,0,1) | Details |
| 11163186 | Petersen M, Brodersen P, Naested H, Andreasson E, Lindhart U, Johansen B, Nielsen HB, Lacy M, Austin MJ, Parker JE, Sharma SB, Klessig DF, Martienssen R, Mattsson O, Jensen AB, Mundy J: Arabidopsis map kinase 4 negatively regulates systemic acquired resistance. Cell. 2000 Dec 22;103(7):1111-20. Analysis of mpk4 expressing the SA hydroxylase NahG and of mpk4/npr1 double mutants indicated that SAR expression in mpk4 is dependent upon elevated SA levels but is independent of NPR1. PDF1.2 and THI2.1 gene induction by jasmonate was blocked in mpk4 expressing NahG, suggesting that MPK4 is required for jasmonic acid-responsive gene expression. |
1(0,0,0,1) | Details |
| 12728993 | Yasuda M, Nakashita H, Hasegawa S, Nishioka M, Arai Y, Uramoto M, Yamaguchi I, Yoshida S: N-cyanomethyl-2-chloroisonicotinamide induces systemic acquired resistance in arabidopsis without accumulation. Biosci Biotechnol Biochem. 2003 Feb;67(2):322-8. Thus, NCI activates SAR, independently from ethylene and jasmonic acid, by stimulating the site between SA and NPR1. |
31(0,1,1,1) | Details |
| 18944464 | Kloepper JW, Ryu CM, Zhang S: Induced Systemic Resistance and Promotion of Plant Growth by Bacillus spp. Phytopathology. 2004 Nov;94(11):1259-66. For example, ISR elicited by several strains of Bacillus spp. is independent of but dependent on jasmonic acid, ethylene, and the regulatory gene NPR1-results that are in agreement with the model for ISR elicited by Pseudomonas spp. |
12(0,0,2,2) | Details |
| 17601164 | Ahn IP, Lee SW, Suh SC: Rhizobacteria-induced priming in Arabidopsis is dependent on ethylene, jasmonic acid, and NPR1. Mol Plant Microbe Interact. 2007 Jul;20(7):759-68. |
12(0,0,2,2) | Details |
| 15255867 | Ryu CM, Murphy JF, Mysore KS, Kloepper JW: Plant growth-promoting rhizobacteria systemically protect Arabidopsis thaliana against Cucumber mosaic virus by a and NPR1-independent and jasmonic acid-dependent signaling pathway. Plant J. 2004 Aug;39(3):381-92. |
12(0,0,2,2) | Details |
| 18586869 | Yasuda M, Ishikawa A, Jikumaru Y, Seki M, Umezawa T, Asami T, Maruyama-Nakashita A, Kudo T, Shinozaki K, Yoshida S, Nakashita H: Antagonistic interaction between systemic acquired resistance and the abscisic acid-mediated abiotic stress response in Arabidopsis. Plant Cell. 2008 Jun;20(6):1678-92. Epub 2008 Jun 27. In an analysis using several mutants in combination with these chemicals, treatment with ABA suppressed SAR induction by inhibiting the pathway both upstream and downstream of SA, independently of the jasmonic acid/ethylene-mediated signaling pathway. Conversely, the activation of SAR suppressed the expression of ABA biosynthesis-related and ABA-responsive genes, in which the NPR1 protein or signaling downstream of NPR1 appears to contribute. |
1(0,0,0,1) | Details |
| 11418340 | Dong X: Genetic dissection of systemic acquired resistance. Curr Opin Plant Biol. 2001 Aug;4(4):309-14. The signal is transduced through NPR1, a nuclear-localized protein that interacts with transcription factors that are involved in regulating -mediated gene expression. |
1(0,0,0,1) | Details |
| 12848424 | Nandi A, Kachroo P, Fukushige H, Hildebrand DF, Klessig DF, Shah J: Ethylene and jasmonic acid signaling affect the NPR1-independent expression of defense genes without impacting resistance to Pseudomonas syringae and Peronospora parasitica in the Arabidopsis ssi1 mutant. Mol Plant Microbe Interact. 2003 Jul;16(7):588-99. |
9(0,0,1,4) | Details |
| 19716624 | Zhang X, Chen S, Mou Z: Nuclear localization of NPR1 is required for regulation of tolerance, isochorismate synthase 1 expression and accumulation in Arabidopsis. J Plant Physiol. 2010 Jan 15;167(2):144-8. Epub . NPR1 also positively regulates SA tolerance and plays a role in SA-mediated negative regulation of jasmonic acid (JA) signaling. |
8(0,0,0,8) | Details |
| 19176718 | Leon-Reyes A, Spoel SH, De Lange ES, Abe H, Kobayashi M, Tsuda S, Millenaar FF, Welschen RA, Ritsema T, Pieterse CM: Ethylene modulates the role of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 in cross talk between and jasmonate signaling. Plant Physiol. 2009 Apr;149(4):1797-809. Epub 2009 Jan 28. The plant hormones (SA), jasmonic acid (JA), and ethylene (ET) play crucial roles in the signaling network that regulates induced defense responses against biotic stresses. In Arabidopsis (Arabidopsis thaliana), NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 (NPR1) was demonstrated to be required for SA-mediated suppression of JA-dependent defenses. |
7(0,0,0,7) | Details |
| 12059104 | Murray SL, Thomson C, Chini A, Read ND, Loake GJ: Characterization of a novel, defense-related Arabidopsis mutant, cir1, isolated by luciferase imaging. Mol Plant Microbe Interact. 2002 Jun;15(6):557-66. The recessive mutant designated cir1 exhibited constitutive expression of (SA), jasmonic acid (JA)/ethylene, and reactive intermediate-dependent genes. Hence, cirl-mediated resistance is established via NPR1-dependent and -independent signaling pathways and SA accumulation is essential for the function of both pathways. |
1(0,0,0,1) | Details |
| 12906111 | Grant JJ, Chini A, Basu D, Loake GJ: Targeted activation tagging of the Arabidopsis NBS-LRR gene, ADR1, conveys resistance to virulent pathogens. Mol Plant Microbe Interact. 2003 Aug;16(8):669-80. This line showed constitutive expression of a number of key defense marker genes and accumulated but not ethylene or jasmonic acid. Analysis of a series of adr1 double mutants suggested that adr1-mediated resistance against P. parasitica was (SA)-dependent, while resistance against E. cichoracearum was both SA-dependent and partially NPR1-dependent. |
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| 19200155 | Zhang S, Yang X, Sun M, Sun F, Deng S, Dong H: -induced priming for pathogen defense in Arabidopsis thaliana. J Integr Plant Biol. 2009 Feb;51(2):167-74. The priming process needed NPR1 (essential regulator of systemic acquired resistance) and maintenance of H (2) O (2) burst but was independent of jasmonic acid, ethylene, and abscisic acid. |
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| 17956859 | Hossain MM, Sultana F, Kubota M, Koyama H, Hyakumachi M: The plant growth-promoting fungus Penicillium simplicissimum GP17-2 induces resistance in Arabidopsis thaliana by activation of multiple defense signals. Plant Cell Physiol. 2007 Dec;48(12):1724-36. Epub 2007 Oct 22. To assess the contribution of different defense pathways, Arabidopsis genotypes implicated in (SA) signaling expressing the NahG transgene or carrying disruption in NPR1 (npr1), jasmonic acid (JA) signaling (jar1) and ethylene (ET) signaling (ein2) were tested. |
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| 19897603 | Kallenbach M, Alagna F, Baldwin IT, Bonaventure G: Nicotiana attenuata SIPK, WIPK, NPR1, and fatty acid-amino acid conjugates participate in the induction of jasmonic acid biosynthesis by affecting early enzymatic steps in the pathway. Plant Physiol. 2010 Jan;152(1):96-106. Epub 2009 Nov 6. |
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| 20037473 | Bonaventure G, Baldwin IT: New insights into the early biochemical activation of jasmonic acid biosynthesis in leaves. Plant Signal Behav. 2010 Mar 19;5(3). In addition, the -induced protein kinase (SIPK) and the nonexpressor of PR-1 (NPR1) participate in this activation mechanism that controls the supply of 18:3. |
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| 16808931 | Kishimoto K, Matsui K, Ozawa R, Takabayashi J: Analysis of defensive responses activated by volatile allo-ocimene treatment in Arabidopsis thaliana. Phytochemistry. 2006 Jul;67(14):1520-9. Epub 2006 Jun 30. This suggested that allo-ocimene could prime defensive responses in Arabidopsis. allo-Ocimene enhanced resistance against B. cinerea in an ethylene resistant mutant (etr1-1), a jasmonic acid resistant mutant (jar1-1) and a resistant mutant (npr1-1). Thus, it is suggested that a signaling pathway independent for ETR1, JAR1 and NPR1 was operative to induce the resistance. |
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| 14615603 | Kachroo A, Lapchyk L, Fukushige H, Hildebrand D, Klessig D, Kachroo P: Plastidial fatty acid signaling modulates - and jasmonic acid-mediated defense pathways in the Arabidopsis ssi2 mutant. Plant Cell. 2003 Dec;15(12):2952-65. Epub 2003 Nov 13. A mutation in the Arabidopsis gene ssi2/fab2, which encodes stearoyl-acyl carrier protein desaturase (S-ACP-DES), results in the reduction of (18:1) levels in the mutant plants and also leads to the constitutive activation of NPR1-dependent and -independent defense responses. |
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| 15634206 | Liu G, Holub EB, Alonso JM, Ecker JR, Fobert PR: An Arabidopsis NPR1-like gene, NPR4, is required for disease resistance. Plant J. 2005 Jan;41(2):304-18. In leaves of wild-type plants, NPR4 mRNA levels increase following pathogen challenge or SA treatment, and decrease rapidly following methyl jasmonic acid (MeJA) treatment. |
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| 17309686 | Yuan Y, Zhong S, Li Q, Zhu Z, Lou Y, Wang L, Wang J, Wang M, Li Q, Yang D, He Z: Functional analysis of rice NPR1-like genes reveals that OsNPR1/NH1 is the rice orthologue conferring disease resistance with enhanced herbivore susceptibility. Plant Biotechnol J. 2007 Mar;5(2):313-24. Different subcellular localizations of OsNPR1 antagonistically regulated SA- and jasmonic acid (JA)-responsive genes, but not SA and JA levels, indicating that OsNPR1 might mediate antagonistic cross-talk between the SA- and JA-dependent pathways in rice. |
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| 15231270 | Pieterse CM, Van Loon LC: NPR1: the spider in the web of induced resistance signaling pathways. Curr Opin Plant Biol. 2004 Aug;7(4):456-64. The plant hormones (SA), jasmonic acid (JA), and ethylene (ET) are major players in the regulation of signaling networks that are involved in induced defense responses against pathogens and insects. |
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| 10810143 | Kachroo P, Yoshioka K, Shah J, Dooner HK, Klessig DF: Resistance to turnip crinkle virus in Arabidopsis is regulated by two host genes and is dependent but NPR1, ethylene, and jasmonate independent. Plant Cell. 2000 May;12(5):677-90. We also demonstrate that HR formation and TCV resistance are dependent on but not on ethylene or jasmonic acid. |
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| 19144005 | Lu H, Salimian S, Gamelin E, Wang G, Fedorowski J, LaCourse W, Greenberg JT: Genetic analysis of acd6-1 reveals complex defense networks and leads to identification of novel defense genes in Arabidopsis. Plant J. 2009 May;58(3):401-12. Epub 2009 Jan 8. In addition, acd6-1 shows ethylene- and jasmonic acid-mediated signaling that is antagonized and therefore masked by the presence of SA. Mutant analysis revealed a new relationship between the signaling components NPR1 and PAD4 and also indicated that multiple defense pathways were required for phenotypes conferred by acd6-1. |
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| 18184065 | Conn VM, Walker AR, Franco CM: Endophytic actinobacteria induce defense pathways in Arabidopsis thaliana. Mol Plant Microbe Interact. 2008 Feb;21(2):208-18. In contrast, resistance to F. oxysporum mediated by Streptomyces sp. strain EN27 occurred via an NPR1-dependent pathway but also required and was JA/ET independent. |
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| 17998535 | Spoel SH, Johnson JS, Dong X: Regulation of tradeoffs between plant defenses against pathogens with different lifestyles. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18842-7. Epub 2007 Nov 12. In these responses, (SA) and jasmonic acid (JA) play important signaling roles. This process was partly dependent on the cross-talk modulator NPR1. |
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