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Nurmberg PL, Knox KA, Yun BW, Morris PC, Shafiei R, Hudson A, Loake GJ: The developmental selector AS1 is an evolutionarily conserved regulator of the plant immune response. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18795-800. Epub 2007 Nov 14.
AS1 is expressed in leaf founder cells, where it functions as a heterodimer with the structurally unrelated AS2 proteins to repress activity of KNOTTED 1-like homeobox (KNOX) genes.
AS1 operates as a negative regulator of inducible resistance against these pathogens by selectively binding to the promoters of genes controlled by the immune activator, jasmonic acid (JA), damping the defense response. |
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