Protein Information

Name SKP1
Synonyms CDK2/Cyclin A associated protein p19A; Cyclin A/CDK2 associated protein p19; EMC19; OCP 2; OCP II; OCP II protein; OCP2; Organ of Corti protein 2…

Compound Information

Name jasmonic acid
CAS

Reference List

PubMed Abstract RScore(About this table)
12445118 Devoto A, Nieto-Rostro M, Xie D, Ellis C, Harmston R, Patrick E, Davis J, Sherratt L, Coleman M, Turner JG: COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis. Plant J. 2002 Nov;32(4):457-66.


Other F-box proteins interact with SKP1 and cullin proteins to form SCF complexes that selectively recruit regulatory proteins targeted for ubiquitination.
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15860010 Ren C, Pan J, Peng W, Genschik P, Hobbie L, Hellmann H, Estelle M, Gao B, Peng J, Sun C, Xie D: Point mutations in Arabidopsis Cullin1 reveal its essential role in jasmonate response. Plant J. 2005 May;42(4):514-24.


The SKP1-Cullin/Cdc53-F-box protein ubiquitin ligases (SCF) target many important regulatory proteins for degradation and play vital roles in diverse cellular processes.
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11117256 del Pozo JC, Estelle M: F-box proteins and protein degradation: an emerging theme in cellular regulation. Plant Mol Biol. 2000 Sep;44(2):123-8.

In plants, the SCF has so far been implicated in floral development, circadian clock, and response to the plant growth regulators auxin and jasmonic acid.
The SCF is composed of a cullin (Cdc53), SKP1, RBX1 and one member of a large family of proteins called F-box proteins.
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12682009 Dharmasiri S, Dharmasiri N, Hellmann H, Estelle M: The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis. EMBO J. 2003 Apr 15;22(8):1762-70.


The related-to-ubiquitin (RUB) protein is post-translationally conjugated to the cullin subunit of the SCF (SKP1, Cullin, F-box) class of ubiquitin protein ligases.
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20159850 Gfeller A, Liechti R, Farmer EE: Arabidopsis jasmonate signaling pathway. Sci Signal. 2010 Feb 16;3(109):cm4.

The prohormone jasmonic acid (JA) is conjugated to amino acids such as isoleucine to form the active hormone jasmonoyl-isoleucine (JA-Ile).
A series of breakthroughs has identified the SCF [SCF consists of four subunits: a cullin, SKP1 (S-phase kinase-associated protein 1), a RING finger protein (RBX1/HRT1/ROC1), and an F-box protein] CORONATINE INSENSITIVE1 (COI1) E3 ubiquitin ligase complex and the JASMONATE ZIM-DOMAIN (JAZ) proteins as central components in the perception of and transcriptional response to JA-Ile.
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