Protein Information

Name DMP1
Synonyms Cyclin D binding myb like transcription factor 1; DMP1; Cyclin D binding Myb like protein beta; Cyclin D binding Myb like protein gamma; Cyclin D binding Myb like protein variant; DMTF; DMTF 1; DMTF1…

Compound Information

Name phosphorus
CAS phosphorus

Reference List

PubMed Abstract RScore(About this table)
20059333 Bergwitz C, Juppner H: Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. . Annu Rev Med. 2010;61:91-104.

Synthesis and secretion of FGF23 by osteocytes are positively regulated by 1,25 (OH)(2) D and serum phosphorus and negatively regulated, through yet unknown mechanisms, by the phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX) and by dentin matrix protein 1 (DMP1).
31(0,1,1,1) Details
20012997 Wesseling-Perry K: FGF-23 in bone biology. Pediatr Nephrol. 2010 Apr;25(4):603-8. Epub 2009 Dec 15.

Recent studies have demonstrated that levels of fibroblast growth factor 23 (FGF-23), a key regulator of phosphorus and vitamin D metabolism, rise dramatically as renal function declines and may play a key initiating role in disordered mineral and bone metabolism in patients with chronic kidney disease (CKD).
FGF-23 and its regulators, including phosphate regulating endopeptidase homolog, dentin matrix 1 (DMP1), and matrix extracellular phosphoglycoprotein, are made primarily in bone, specifically in osteocytes.
2(0,0,0,2) Details