Protein Information

Name osteoprotegerin
Synonyms OCIF; OPG; TNFRSF11B; TR1; Osteoclastogenesis inhibitory factor; Osteoprotegerin; Tumor necrosis factor receptor superfamily member 11B; Tumor necrosis factor receptor superfamily member 11B precursor…

Compound Information

Name phosphorus
CAS phosphorus

Reference List

PubMed Abstract RScore(About this table)
19345526 Torres PA: [Origin of the mediacalcosis in kidney failure] . J Mal Vasc. 2009 May;34(3):204-10. Epub 2009 Apr 3.

It is now possible to identify factors clearly favoring the formation of VC: TNF-alpha (which stimulates cell necrosis/apoptosis), CRP, oxidized lipids, AGEs, leptin, inorganic phosphate, high calcium-phosphorus product (CaxPO (4)), calcium, 1,25-OH (2) D (3) and Vitamin D (3), PTHrP (via an intracrine pathway), cyclic AMP, TGF-beta, bone morphogenic protein 2 (BMP2) and factors protective against the formation of VC: magnesium, HDL, inorganic pyrophosphate, albumin, ahsg/fetuin A, osteopontin (OPN), osteoprotegerin (OPG), osteonectin (ON), bone morphogenic protein 7 (BMP7), klotho, PTHrP (via a paracrine pathway), matrix gla protein (MGP), PTH (via Msx2) and vitamin K.
31(0,1,1,1) Details
20124547 Avila M, Prado C, Ventura MD, Mora C, Briones D, Valdez H, Hurtado ME, Lindholm B, Qureshi A, Castillo-Henkel C, Paniagua R: Vitamin D receptor gene, biochemical bone markers and bone mineral density in Mexican women on dialysis. Nephrol Dial Transplant. 2010 Feb 2.

METHODS: In a cross-sectional study, 197 women (42 +/- 10 years; 25% with diabetes mellitus (DM); body mass index (BMI) 25.26 +/- 4.77 kg/m (2)) treated by PD (72%) or HD (28%) underwent measurements of BMD (measured at the calcaneus by quantitative ultrasound; expressed as T- and Z-scores) and plasma total calcium (tCa), intact parathyroid hormone 1-84 (iPTH), phosphorus, albumin, glucose, osteoprotegerin (OPG), fetuin-A, intact osteocalcin-49 and N-MID fragment 1-43 aa (N-MID osteocalcin) N-terminal propeptide of type 1 procollagen (PINP) and C-terminal telopeptide-beta aspartic acid (BCL).
6(0,0,1,1) Details
20211333 Akat K, Kaden JJ, Schmitz F, Ewering S, Anton A, Klomfass S, Hoffmann R, Ortlepp JR: Calcium metabolism in adults with severe aortic valve stenosis and preserved renal function. Am J Cardiol. 2010 Mar 15;105(6):862-4.

To further investigate this, the following parameters were analyzed in 38 patients with severe AS and in 38 age- and gender-matched controls, without obstructive coronary artery disease and with preserved renal function: calcium, phosphate, 1,25 (OH (2))-vitamin D (3), intact parathyroid hormone (iPTH), and osteoprotegerin.
Patients with AS had significantly higher serum levels of calcium (2.63 +/- 0.28 vs 2.48 +/- 0.23 mmol/L, p <0.01) and phosphate (1.56 +/- 0.33 vs 1.38 +/- 0.26 mmol/L, p <0.01) and increased calcium-phosphorus products (4.16 +/- 1.13 vs 3.44 +/- 0.89 mmol/L (2), p = 0.003).
3(0,0,0,3) Details