| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | phosphorus |
|---|---|
| CAS | phosphorus |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19737786 | Eddleston M, Worek F, Eyer P, Thiermann H, Von Meyer L, Jeganathan K, Sheriff MH, Dawson AH, Buckley NA: Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos. QJM. 2009 Nov;102(11):785-92. Epub 2009 Sep 8. BACKGROUND: Many organophosphorus (OP) insecticides have either two O-methyl or two O-ethyl groups attached to the phosphorus atom. This chemical structure affects their responsiveness to oxime-induced acetylcholinesterase (AChE) reactivation after poisoning. |
1(0,0,0,1) | Details |
| 20132373 | Schofield DA, Dinovo AA: Generation of a mutagenized organophosphorus hydrolase for the biodegradation of the organophosphate pesticides malathion and demeton-S. J Appl Microbiol. 2010 Jan 11. Abstract Aims: The bacterial organophosphorus hydrolase (OPH) enzyme hydrolyses and detoxifies a broad range of toxic organophosphate pesticides and warfare nerve agents by cleaving the various phosphorus-ester bonds (P-O, P-F, P-CN, P-S); however, OPH hydrolyses these bonds with varying efficiencies. Activity was associated with organophosphate detoxification as the hydrolysed substrate lost the ability to inhibit acetylcholinesterase. |
1(0,0,0,1) | Details |
| 20338153 | Masson P, Nachon F, Lockridge O: Structural approach to the aging of phosphylated cholinesterases. . Chem Biol Interact. 2010 Mar 23. Determination of the three-dimensional structure of BChE and AChE conjugated to different OPs showed that aged adducts form a salt bridge with the protonated catalytic It was assumed that the resulting negatively charged atom on phosphorus of the aged adduct prevented nucleophilic attack by oximates, but studies on negatively charged model molecules do not support this hypothesis. |
1(0,0,0,1) | Details |
| 19574615 | Tsakiris T, Angelogianni P, Tesseromatis C, Tsakiris S, Schulpis KH: L-cysteine's effect on modulated rat brain enzymes with forced swimming. Int J Sport Nutr Exerc Metab. 2009 Jun;19(3):285-97. RESULTS: TAS concentration (55.6 +/- 1.5 vs. 42.1 +/- 1.0 vs. 37.4 +/- 1.2 micromol/L, p < .001), protein concentration (5.68 +/- 0.36 vs. 5.40 +/- 0.18 vs. 4.01 +/- 0.16 mg/ml, p < .01), and AChE activity (0.89 +/- 0.05 vs. 0.61 +/- 0.04 vs. 0.48 +/- 0.03 DeltaOD/min x mg protein, p < .001) were significantly reduced, whereas Na+,K+-ATPase (6.00 +/- 0.36 vs. 10.44 +/- 1.04 vs. 11.90 +/- 1.21 micromol phosphorus inorganic/hr x mg protein, p < .001) and Mg2+-ATPase activity (7.20 +/- 0.65 vs. 10.88 +/- 1.08 vs. 11.55 +/- 1.22 mmol phosphorus inorganic/hr x mg protein, p < .001) were statistically significantly increased after 2 and 3 hr of forced exercise. |
33(0,1,1,3) | Details |
| 19642642 | Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P, Silman I, Weik M: Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime. J Med Chem. 2009 Dec 10;52(23):7593-603. Furthermore, the crystal structure of the ternary complex of the aged conjugate with 2-PAM revealed that the orientation of the oxime function does not permit nucleophilic attack on the phosphorus atom, thus providing a plausible explanation for its failure to reactivate the aged soman/AChE conjugate. |
5(0,0,0,5) | Details |
| 20156428 | Beck JM, Hadad CM: Reaction profiles of the interaction between sarin and acetylcholinesterase and the S203C mutant: Model nucleophiles and QM/MM potential energy surfaces. Chem Biol Interact. 2010 Feb 13. Calculations utilizing small model nucleophiles indicate that the reaction barrier for addition to GB is the rate-limiting step for both ethoxide and ethyl thiolate (CH (3) CH (2) S (-)); moreover, the activation barrier for addition to the phosphorus center of GB by ethyl thiolate is significantly larger (13.2kcal/mol) than for ethoxide (8.3kcal/mol). |
5(0,0,0,5) | Details |
| 19715346 | Barakat NH, Zheng X, Gilley CB, MacDonald M, Okolotowicz K, Cashman JR, Vyas S, Beck JM, Hadad CM, Zhang J: Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2009 Oct;22(10):1669-79. Both G and V type nerve agents possess a center of chirality about phosphorus. |
4(0,0,0,4) | Details |
| 20347727 | Moralev SN, Tikhonov DB: INVESTIGATION OF STRUCTURE-ACTIVITY RELATIONSHIPS IN ORGANOPHOSPHATES-CHOLINESTERASE INTERACTION USING DOCKING ANALYSIS. Chem Biol Interact. 2010 Mar 25. It is known than the most potent homologues in various series of O,O-dialkylphosphates are the dibutyl or diamyl derivatives toward mammalian cholinesterases (ChEs) (both Acetyl- and Butyryl-ChEs), and the dimethyl or diethyl ones toward insect AChEs. in this position creates sterical hindrance for proper orientation of the OPI molecule, which increases the distance between the catalytic serine gamma- and phosphorus, and decreases the angle of nucleophylic attack. |
4(0,0,0,4) | Details |
| 19928287 | Jha N, Ramaprabhu S: Development of MWNT based disposable biosensor on glassy carbon electrode for the detection of organophosphorus nerve agents. J Nanosci Nanotechnol. 2009 Sep;9(9):5676-80. The development of a disposable Acetylcholinesterase (AChE) based biosensor is described. Biosensing activity of functionalized multi walled carbon nanotubes (MWNTs) towards the detection of Organo phosphorus (OP) compound, paraoxon, has been tested using Amperometric method. |
2(0,0,0,2) | Details |