| Name | calcium sensing receptor |
|---|---|
| Synonyms | CAR; CAR; CASR; Calcium sensing receptor; Extracellular calcium sensing receptor; Extracellular calcium sensing receptor precursor; FHH; FIH… |
| Name | phosphorus |
|---|---|
| CAS | phosphorus |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 20151157 | Cannata-Andia JB, Rodriguez-Garcia M, Roman-Garcia P, Tunon-le Poultel D, Lopez-Hernandez F, Rodriguez-Puyol D: New therapies: calcimimetics, binders and receptor activators. Pediatr Nephrol. 2010 Apr;25(4):609-16. Epub 2010 Feb 12. At present, new compounds are available to treat secondary hyperparathyroidism, namely calcimimetics, novel phosphorus binders and also novel receptor activators. Calcimimetics increase the sensitivity of the parathyroid gland to through spatial configurational changes of the calcium-sensing receptor. |
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| 19321594 | Lopez I, Mendoza FJ, Guerrero F, Almaden Y, Henley C, Aguilera-Tejero E, Rodriguez M: The calcimimetic AMG 641 accelerates regression of extraosseous calcification in uremic rats. Am J Physiol Renal Physiol. 2009 Jun;296(6):F1376-85. Epub 2009 Mar 25. The purpose of the present study was to test the hypothesis that extraskeletal calcification regresses in uremic rats after reduction in phosphorus intake and treatment with calcimimetics. An infiltrate of phagocytic cells expressing the calcium-sensing receptor was identified in areas surrounding foci of calcification. |
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| 19615558 | McKay CP, Portale A: Emerging topics in pediatric bone and mineral disorders 2008. Semin Nephrol. 2009 Jul;29(4):370-8. The calcium sensing receptor (CaSR) and fibroblast growth factor 23 (FGF-23) play central roles in the regulation of and phosphorus metabolism, respectively. The calcium sensing receptor (CaSR) and fibroblast growth factor 23 (FGF-23) play central roles in the regulation of and phosphorus metabolism, respectively. |
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| 19715856 | Gomez Marques G, Obrador Mulet A, Vilar Gimeno A, Pascual Felip MJ, Alarcon Zurita A, Molina Guasch M, Uriol Rivera M, Munar Vila MA, Losada Gonzalez P: Treatment with cinacalcet of secondary hyperparathyroidism after renal transplantation. Transplant Proc. 2009 Jul-Aug;41(6):2139-43. Calcimimetics inhibit parathyroid hormone (PTH) secretion by modulating the calcium-sensing receptor in the parathyroid gland. |
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| 19299893 | Taylor JG, Bushinsky DA: and phosphorus homeostasis. Blood Purif. 2009;27(4):387-94. Epub 2009 Mar 23. The identification of subfamily V transient receptor potential cation channels (TRPV channels), Na/P (i) cotransporters, the receptor and the calcium-sensing receptor have further advanced our understanding of this complex physiology. |
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| 19295196 | Cozzolino M, Ciceri P, Volpi EM, Olivi L, Messa PG: Pathophysiology of and metabolism impairment in chronic kidney disease. Blood Purif. 2009;27(4):338-44. Epub 2009 Mar 18. However, in the presence of low high phosphorus, deficiency, and uremia, PT cells leave quiescence. In the last decade, both new molecular and cellular mechanisms have been investigated in the pathophysiology of SHPT, between them the emerging role of the PT receptor and calcium-sensing receptor. |
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| 19549251 | Goswami R, Goel S, Tomar N, Gupta N, Lumb V, Sharma YD: Prevalence of clinical remission in patients with sporadic idiopathic hypoparathyroidism. Clin Endocrinol. 2009 Jun 22. Calcium sensing receptor autoantibodies (CaSRAb) were determined by western blot. Remission of SIH was defined as maintenance of normal serum total (>/=2.12 mmol/L) and ionized inorganic phosphorus and iPTH for at least three months after withdrawal of and 1-alpha-(OH) D (3)/ therapy. |
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| 19560849 | Giannikopoulos G, Zorzou MP, Stamoulis I, Panagi G, Sitaras P, Georgopoulos I, Hadjileontis C, Malakos I, Kyriazis J: Cinacalcet-induced leukocytoclastic vasculitis. . Am J Kidney Dis. 2009 Aug;54(2):e5-8. Epub 2009 Jun 28. Cinacalcet targets the calcium-sensing receptor and decreases parathyroid hormone levels without increasing and phosphorus levels. |
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| 20150282 | Sun W, Sun W, Liu J, Zhou X, Xiao Y, Karaplis A, Pollak MR, Brown E, Goltzman D, Miao D: Alterations in phosphorus, and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice. Development. 2010 Mar;137(6):985-92. Epub 2010 Feb 11. |
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| 20091482 | Caudrillier A, Mentaverri R, Brazier M, Kamel S, Massy ZA: Calcium-sensing receptor as a potential modulator of vascular calcification in chronic kidney disease. J Nephrol. 2010 Jan-Feb;23(1):17-22. Calcimimetics have been demonstrated to be particularly useful to control parathyroid hormone (PTH) oversecretion and concomitantly reduce serum Ca2+ and phosphorus levels in dialysis patients. |
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| 20200973 | Richard C, Huo R, Samadfam R, Bolivar I, Miao D, Brown EM, Hendy GN, Goltzman D: The calcium sensing receptor and -1alpha-hydroxylase interact to modulate skeletal growth and bone turnover. J Bone Miner Res. 2010 Feb 8. On a high high high phosphorus "rescue" diet, serum and PTH were normal in the 1alpha (OH) ase (-/-) mice, but increased in the Casr (-/-) 1alpha (OH) ase (-/-) mice with reduced serum phosphorus. |
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| 19355939 | Theman TA, Collins MT: The role of the calcium-sensing receptor in bone biology and pathophysiology. Curr Pharm Biotechnol. 2009 Apr;10(3):289-301. Complex endocrine feedback loops involving phosphorus, and PTH confound efforts to isolate the effects of a single mineral, hormone, or receptor and most models fail to account for other local factors such as parathyroid hormone related protein (PTHrP). |
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| 19396314 | Carrillo-Lopez N, Fernandez-Martin JL, Cannata-Andia JB: [The role of and their receptors in parathyroid regulation]. Nefrologia. 2009;29(2):103-8. doi: 10.3265/Nefrologia.2009.29.2.5154.en.full. The mechanism of regulation of Parathyroid hormone (PTH) is complex, and diverse factors are involved: the fundamental ones are and phosphorus. and calcitriol's mechanism of action takes place through its specific receptors, the calcium-sensing receptor (CaR) and the Receptor (VDR). |
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