Protein Information

Name interleukin 6
Synonyms 26 kd protein; B cell differentiation factor; B cell stimulatory factor 2; BSF 2; BSF2; CDF; CTL differentiation factor; HGF…

Compound Information

Name phosphorus
CAS phosphorus

Reference List

PubMed Abstract RScore(About this table)
20091488 Cottone S, Palermo A, Arsena R, Riccobene R, Guarneri M, Mule G, Tornese F, Altieri C, Vaccaro F, Previti A, Cerasola G: Relationship of fetuin-A with glomerular filtration rate and endothelial dysfunction in moderate-severe chronic kidney disease. J Nephrol. 2010 Jan-Feb;23(1):62-9.

Multiple regression analysis showed that fetuin-A was independently associated with estimated glomerular filtration rate (beta=0.386; p <0.001), IL-6 (beta=-0.393; p=0.001) and ET-1 (beta=-0.219; p=0.02), in a multivariate model including also sex, parathyroid hormone and the calcium x phosphorus product.
34(0,1,1,4) Details
19827189 Berezhnova IA, Korshunov GV: [Plasma lipids and interleukins in geriatric patients with ischemic heart disease]. Klin Lab Diagn. 2009 Aug;(8):3-6.

The serum levels of total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, apoA- and apoB-lipoproteins, calcium, phosphorus, alkaline phosphatase, etc. were measured on a Vitalab Flexor E. biochemical analyzer.
The increased levels of interleukin (IL)-1 beta and IL-6 suggest that there is an inflammatory reaction whereas those of tumor necrosis factor-alpha may be indicative of the body's autoimmune readiness.
3(0,0,0,3) Details
19690405 Hasuike Y, Nonoguchi H, Ito K, Naka M, Kitamura R, Nanami M, Tokuyama M, Kida A, Otaki Y, Kuragano T, Nakanishi T: Interleukin-6 is a predictor of mortality in stable hemodialysis patients. Am J Nephrol. 2009;30(4):389-98. Epub 2009 Aug 19.

In stepwise multiple regression analyses, age, phosphorus and high-sensitivity C-reactive protein were independent predictors of IL-6 (R (2) = 0.466, p < 0.0001).
12(0,0,1,7) Details
19808245 Navarro-Gonzalez JF, Mora-Fernandez C, Muros M, Herrera H, Garcia J: Mineral metabolism and inflammation in chronic kidney disease patients: a cross-sectional study. Clin J Am Soc Nephrol. 2009 Oct;4(10):1646-54. Epub 2009 Sep 24.


After adjustment for age, gender, and eGFR, the levels of C-reactive protein (CRP) and IL-6 (IL-6) of the third tertile of P, Ca x P, and PTH were significantly higher than those of the first and second tertiles.
4(0,0,0,4) Details
19967658 Ferreira A, Saraiva M, Behets G, Macedo A, Galvao M, D'Haese P, Drueke TB: Evaluation of bone remodeling in hemodialysis patients: serum biochemistry, circulating cytokines and bone histomorphometry. J Nephrol. 2009 Nov-Dec;22(6):783-93.

Circulating levels of interleukin-6 (IL-6), IL-1 receptor antagonist (IL-1Ra) and soluble IL-6 receptor (sIL-6r) were determined using ELISA.
Serum calcium and phosphorus, however, did not differ (p=NS).
3(0,0,0,3) Details
19621176 Kunstmann S, Vukusich A, Michea L, Varela C, Allende I, Bravo S, Gainza D, Sepulveda D, Marusic E, Figueroa F: [Cardiovascular assessment of non diabetic patients on hemodialysis] . Rev Med Chil. 2009 Mar;137(3):351-60. Epub 2009 Jun 15.

No correlations were found between ventricular hypertrophy and dialysis lapse, packed red cell volume, calcium phosphorus product, parathormone levels or median arterial pressure.
In 26 patients, interleukin 6, tumor necrosis factor alpha, and intercellular adhesion molecule (ICAM-1) were also measured.
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19513005 Li N, Qin LP, Han T, Wu YB, Zhang QY, Zhang H: Inhibitory effects of morinda officinalis extract on bone loss in ovariectomized rats. Molecules. 2009 Jun 8;14(6):2049-61.


Administration of RMO extract increased trabecular bone mineral content and bone mineral density of tibia, improved the levels of phosphorus (P), calcium (Ca) and OPG, decreased the levels of DPD/Cr, TRAP, ACTH and corticosterone, but did not reverse the levels of ALP, TNF-alpha and IL-6 in serum of ovariectomized rats.
0(0,0,0,0) Details