Protein Information

Name osteopontin
Synonyms BNSP; Spp1; BSPI; Bone sialoprotein; Bone sialoprotein 1; ETA 1; ETA1; Early T lymphocyte activation 1…

Compound Information

Name phosphorus
CAS phosphorus

Reference List

PubMed Abstract RScore(About this table)
19322138 El-Abbadi MM, Pai AS, Leaf EM, Yang HY, Bartley BA, Quan KK, Ingalls CM, Liao HW, Giachelli CM: Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin. Kidney Int. 2009 Jun;75(12):1297-307. Epub 2009 Mar 25.
8(0,0,1,3) Details
19789408 Ishizeki K, Kagiya T, Fujiwara N, Otsu K, Harada H: Expression of osteogenic proteins during the intrasplenic transplantation of Meckel's chondrocytes: A histochemical and immunohistochemical study. Arch Histol Cytol. 2009 Mar;72(1):1-12.


Type I, II, and X collagens, and the bone-marker proteins osteocalcin, osteopontin, osteonectin, and bone morphogenetic protein-2 (BMP-2) were immunolocalized in the matrix formed by the transplanted chondrocytes.
2(0,0,0,2) Details
20004751 Sethuraman S, Nair LS, El-Amin S, Nguyen MT, Singh A, Krogman N, Greish YE, Allcock HR, Brown PW, Laurencin CT: Mechanical properties and osteocompatibility of novel biodegradable alanine based polyphosphazenes: Side group effects. Acta Biomater. 2009 Dec 24.

Moreover, cells on the surface of the polymers expressed type I collagen, alkaline phosphatase, osteocalcin, osteopontin, and bone sialoprotein, which are characteristic genes for osteoblast maturation, differentiation, and mineralization.
Biodegradable polyphosphazenes are high-molecular-weight polymers with alternating nitrogen and phosphorus atoms in the backbone.
1(0,0,0,1) Details
19621927 Costa-Pinto AR, Correlo VM, Sol PC, Bhattacharya M, Charbord P, Delorme B, Reis RL, Neves NM: Osteogenic differentiation of human bone marrow mesenchymal stem cells seeded on melt based chitosan scaffolds for bone tissue engineering applications. Biomacromolecules. 2009 Aug 10;10(8):2067-73.

The presence of mineralized extracellular matrix (ECM) was successfully demonstrated by peaks corresponding to calcium and phosphorus elements detected in the EDS analysis.
Moreover, by reverse transcriptase (RT)-PCR analysis, it was observed the expression of osteogenic gene markers, namely, Runt related transcription factor 2 (Runx2), type 1 collagen, bone sialoprotein (BSP), and osteocalcin.
1(0,0,0,1) Details
19601862 Brancaccio D, Bellasi A, Cozzolino M, Galassi A, Gallieni M: Arterial accelerated aging in dialysis patients: the clinical impact of vascular calcification. Curr Vasc Pharmacol. 2009 Jul;7(3):374-80.


Indeed, the co-localization of bone markers such as Osteopontin, Alkaline Phosphatase and Osteocalcin along with osteoblast-like cells in the contest of the arterial wall of uremic patients, indicate that VC is an active biological process with peculiar analogies with bone mineralization.
1(0,0,0,1) Details
19345526 Torres PA: [Origin of the mediacalcosis in kidney failure] . J Mal Vasc. 2009 May;34(3):204-10. Epub 2009 Apr 3.

It is now possible to identify factors clearly favoring the formation of VC: TNF-alpha (which stimulates cell necrosis/apoptosis), CRP, oxidized lipids, AGEs, leptin, inorganic phosphate, high calcium-phosphorus product (CaxPO (4)), calcium, 1,25-OH (2) D (3) and Vitamin D (3), PTHrP (via an intracrine pathway), cyclic AMP, TGF-beta, bone morphogenic protein 2 (BMP2) and factors protective against the formation of VC: magnesium, HDL, inorganic pyrophosphate, albumin, ahsg/fetuin A, osteopontin (OPN), osteoprotegerin (OPG), osteonectin (ON), bone morphogenic protein 7 (BMP7), klotho, PTHrP (via a paracrine pathway), matrix gla protein (MGP), PTH (via Msx2) and vitamin K.
31(0,1,1,1) Details
19546357 Zhou YB, Jin SJ, Cai Y, Teng X, Chen L, Tang CS, Qi YF: Lanthanum acetate inhibits vascular calcification induced by vitamin D3 plus nicotine in rats. Exp Biol Med. 2009 Aug;234(8):908-17. Epub 2009 Jun 22.

As compared with control rats, rats with calcification showed widespread calcified nodules and irregular elastic fibers in calcified aorta on von Kossa calcium staining and increased aortic calcium and phosphorus contents, alkaline phosphatase (ALP) activity and bone-related protein expressions for osteopontin (OPN) and type III sodium dependent phosphate cotransporter Pit-1 (Pit-1).
6(0,0,1,1) Details
19913918 Das S, Sinha S, Britto R, Somasundaram K, Samuelson AG: Cytotoxicity of half sandwich ruthenium (II) complexes with strong hydrogen bond acceptor ligands and their mechanism of action. J Inorg Biochem. 2010 Feb;104(2):93-104. Epub 2009 Oct 8.

In cationic complexes, X, Y is either a eta (2) phosphorus ligand such as 1,1-bis (diphenylphosphino) methane (DPPM) and 1,2-bis (diphenylphosphino) ethane (DPPE) or partially oxidized ligands such as 1,2-bis (diphenylphosphino) methane monooxide (DPPMO) and 1,2-bis (diphenylphosphino) ethane monooxide (DPPEO) which are strong hydrogen bond acceptors.
Complexes with DPPM and DPPMO ligands ([(eta (6)-cymene) Ru (eta (2)-DPPM) Cl] PF (6) (R2), [(eta (6)-cymene) Ru (eta (2)-DPPMO) Cl] PF (6) (R3), [(eta (6)-cymene) Ru (eta (1)-DPPM) Cl (2)] (R5) and [(eta (6)-cymene) Ru (eta (1)-DPPMO) Cl (2)] (R6) show good cytotoxicity.
1(0,0,0,1) Details