Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name phosphorus
CAS phosphorus

Reference List

PubMed Abstract RScore(About this table)
20122814 Delgado-Andrade C, Seiquer I, Garcia MM, Galdo G, Navarro MP: Increased Maillard reaction products intake reduces phosphorus digestibility in male adolescents. Nutrition. 2010 Jan 30.

Serum phosphorus, parathyroid hormone, and total alkaline phosphatase were determined.
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20185967 Wu W, Sun Z, Yu J, Meng Q, Wang M, Miao J, Sun L: A clinical retrospective analysis of factors associated with apathetic hyperthyroidism. Pathobiology. 2010;77(1):46-51. Epub 2010 Feb 25.

METHODS: We retrospectively examined serum calcium, phosphorus and bone-specific alkaline phosphatase (BAP) levels and thyroid-associated variables in 140 patients with apathetic hyperthyroidism, 456 patients with typical hyperthyroidism and 120 healthy subjects.
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20144552 Menon B, Harinarayan CV: The effect of anti epileptic drug therapy on serum 25-hydroxyvitamin D and parameters of calcium and bone metabolism--a longitudinal study. Seizure. 2010 Apr;19(3):153-8. Epub 2010 Feb 7.

Base line bone mineral parameters - serum calcium, phosphorus, alkaline phosphatase (SAP), tartrate resistant acid phosphatase (TRACP), 25 (OH) D levels, parathyroid hormone (PTH) and urinary calcium creatinine ratio (Ca.Cr), urinary calcium/kg/bodyweight (BW) and phosphate excretion index (PEI) were determined.
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19308412 Gaal J, Bender T, Varga J, Horvath I, Kiss J, Somogyi P, Suranyi P: Overcoming resistance to bisphosphonates through the administration of alfacalcidol: results of a 1-year, open follow-up study. Rheumatol Int. 2009 Mar 24.

However, the serum alkaline phosphatase activity, phosphorus, parathormone, osteocalcin levels and the urinary D: -pyr/creatinine ratio decreased significantly (P < 0.001).
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19546357 Zhou YB, Jin SJ, Cai Y, Teng X, Chen L, Tang CS, Qi YF: Lanthanum acetate inhibits vascular calcification induced by vitamin D3 plus nicotine in rats. Exp Biol Med. 2009 Aug;234(8):908-17. Epub 2009 Jun 22.

As compared with control rats, rats with calcification showed widespread calcified nodules and irregular elastic fibers in calcified aorta on von Kossa calcium staining and increased aortic calcium and phosphorus contents, alkaline phosphatase (ALP) activity and bone-related protein expressions for osteopontin (OPN) and type III sodium dependent phosphate cotransporter Pit-1 (Pit-1).
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19862503 Allam AA, El-Ghareeb AW, Abdul-Hamid M, Bakery AE, Gad M, Sabri M: Effect of prenatal and perinatal acrylamide on the biochemical and morphological changes in liver of developing albino rat. Arch Toxicol. 2010 Feb;84(2):129-41. Epub 2009 Oct 28.

Sodium and potassium concentrations were increased, but calcium, phosphorus and iron levels were significantly reduced in the serum.
Acrylamide treatment increased serum alanine aminotransferase and aspartate aminotransferase activities and inhibited alkaline phosphatase activity.
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19863009 Demeterova M, Mariscakova R, Pistl J, Nad P, Samudovska A: The effect of the probiotic strain Enterococcus faecium DSM 7134 in combination with natural humic substances on performance and health of broiler chickens. Berl Munch Tierarztl Wochenschr. 2009 Sep-Oct;122(9-10):370-7.

There were no significant differences among groups in the serum levels of total protein, glucose, cholesterol, aminotransferase and phosphorus.
A significant decrease of total lipids in the probiotic group (P < 0.01) and probiotic + HS group (P < 0.001) groups, triglycerides levels in the HS (P < 0.01), probiotic and probiotic + HS (P < 0.001) groups on day 35, calcium level of the probiotic (P < 0.05) and probiotic + HS (P < 0.01) groups on day 41 and alkaline phosphatase levels in the probiotic group (P < 0.01) on day 14 were observed in comparison to the control group.
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19298641 Abdul Gafor AH, Saidin R, Loo CY, Mohd R, Zainudin S, Shah SA, Norella KC: Intravenous calcitriol versus paricalcitol in haemodialysis patients with severe secondary hyperparathyroidism. Nephrology. 2009 Aug;14(5):488-92. Epub 2009 Mar 10.

Serum iPTH, calcium, phosphorus and alkaline phosphatase were measured at the beginning of the study and every 3 weeks for 12 weeks.
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19563291 Liu K, Meng H, Tang X, Xu L, Zhang L, Chen Z, Shi D, Feng X, Lu R: Elevated plasma calcifediol is associated with aggressive periodontitis. . J Periodontol. 2009 Jul;80(7):1114-20.

The purpose of this study was to evaluate whether an association exists between plasma calcifediol concentrations and aggressive periodontitis (AgP) and whether plasma levels of bone-related biomarkers (osteocalcin, alkaline phosphatase, calcium, and phosphorus) regulated by vitamin D are related to AgP.
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19601862 Brancaccio D, Bellasi A, Cozzolino M, Galassi A, Gallieni M: Arterial accelerated aging in dialysis patients: the clinical impact of vascular calcification. Curr Vasc Pharmacol. 2009 Jul;7(3):374-80.


Indeed, the co-localization of bone markers such as Osteopontin, Alkaline Phosphatase and Osteocalcin along with osteoblast-like cells in the contest of the arterial wall of uremic patients, indicate that VC is an active biological process with peculiar analogies with bone mineralization.
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19776531 Hagihara Y, Nakajima A, Fukuda S, Goto S, Iida H, Yamazaki M: Running exercise for short duration increases bone mineral density of loaded long bones in young growing rats. Tohoku J Exp Med. 2009 Oct;219(2):139-43.

BMD of the tibia was measured using peripheral quantitative computed tomography, and serum levels of tartarate-resistant acid phosphatase (TRAP), a bone resorption marker and alkaline phosphatase (ALP), a bone formation marker were measured to know whether the treadmill exercise would affect systemic bone metabolism.
Short-duration running exercise (30 min/day) caused a significant increase in BMD of the metaphyseal trabecula (p < 0.05) with a reduction of serum TRAP levels (p < 0.01) and an increase in serum levels of calcium (p < 0.05) and phosphorus (p < 0.01).
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20067873 El-Edel RH, Ghonaim MM, Abo-Salem OM, El-Nemr FM: Bone mineral density and vitamin D receptor polymorphism in beta-thalassemia major. Pak J Pharm Sci. 2010 Jan;23(1):89-96.

Serum levels of alkaline phosphatase, calcium, phosphorus, ferritin and 25-hydroxyvitamin D3 were determined.
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19906143 Liu N, Ru YJ, Li FD: Effect of dietary phytate and phytase on metabolic change of blood and intestinal mucosa in chickens. J Anim Physiol Anim Nutr. 2009 Nov 11.

Diets containing phytate phosphorus (0.22% or 0.44%) with phytase supplementation (0, 500 or 1000 U/kg) were administrated to 504 Cobb chicks for 4 weeks.
In the duodenum, phytate decreased the level of T-AOC by 13% (p < 0.05), whereas phytase increased the levels of T-SOD, T-AOC and alkaline phosphatase (ALP) by 9-16% (p < 0.05).
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19948879 Kan WC, Chien CC, Wu CC, Su SB, Hwang JC, Wang HY: Comparison of low-dose deferoxamine versus standard-dose deferoxamine for treatment of aluminium overload among haemodialysis patients. Nephrol Dial Transplant. 2009 Nov 30.

Serum corrected calcium and ferritin decreased in both groups, while serum total alkaline phosphatase increased in both groups.
Serum phosphorus increased in low-dose group (P = 0.029), while plasma intact parathyroid hormone increased in standard-dose group (P = 0.004).
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19587481 Zhu X, Zhai H, Tang SF, Cheng Y: Intrathyroidal parathyroid adenoma presenting with neuromuscular manifestation. Neurol India. 2009 May-Jun;57(3):340-3.

Serum calcium, alkaline phosphatase, and parathyroid hormone were elevated and serum phosphorus was low.
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19555381 Orchard ED, Webb EA, Dyhrman ST: Molecular analysis of the phosphorus starvation response in Trichodesmium spp. Environ Microbiol. 2009 Sep;11(9):2400-11. Epub 2009 Jun 25.

The induction of alkaline phosphatase activity corresponded with phoA and phoX expression, but enzyme activity persisted after the expression of these genes returned to basal levels.
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19586040 Yang XZ, Sun TM, Dou S, Wu J, Wang YC, Wang J: Block copolymer of polyphosphoester and poly (L-lactic acid) modified surface for enhancing osteoblast adhesion, proliferation, and function. Biomacromolecules. 2009 Aug 10;10(8):2213-20.

X-ray photoelectron spectra measurements revealed that phosphorus atomic compositions after surface modification increased from 2.09% to 4.39% with increasing PEEP length of PLLA-b-PEEP from 58 to 224 units, which also led to a more hydrophilic surface property compared with unmodified PLLA.
Moreover, cellular alkaline phosphatase activity and mineral calcium depositions were also promoted by PEEP modification.
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19371801 Patel TV, Singh AK: Kidney disease outcomes quality initiative guidelines for bone and mineral metabolism: emerging questions. Semin Nephrol. 2009 Mar;29(2):105-12.

In the past 5 years, with the publication of several randomized controlled trials, large observational studies, and smaller clinical series, significant progress has been made in our understanding of mineral metabolism, calcium and phosphorus management, and the use of activated vitamin D irrespective of parathyroid hormone level in chronic kidney disease.
More recently, fibroblast growth factor-23 and serum alkaline phosphatase have been shown to predict mortality in dialysis patients, making these attractive markers to monitor.
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19615963 Nakatani S, Mano H, Sampei C, Shimizu J, Wada M: Chondroprotective effect of the bioactive peptide prolyl-hydroxyproline in mouse articular cartilage in vitro and in vivo. Osteoarthritis Cartilage. 2009 Dec;17(12):1620-7. Epub 2009 Jul 8.

In this study, mice that were fed diets containing excess phosphorus were used as an in vivo model.
The in vitro effects of CH, Pro-Hyp, amino acids and other peptides on proliferation, differentiation, glycosaminoglycan content and mineralization of chondrocytes were determined by MTT activity and staining with alkaline phosphatase, alcian blue and alizarin red.
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20194574 Oyedemi S, Yakubu M, Afolayan A: Effect of aqueous extract of Leonotis leonurus (L.) R. Hum Exp Toxicol. 2010 Mar 1.

The extract did not significantly (p > .05) alter the levels of haemoglobin, packed cell volume, mean corpuscular volume, red cell distribution width, basophils, total protein, phosphorus, calcium and chloride ions of the animals.
Whereas the levels of lymphocytes, eosinophils, monocytes, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, atherogenic index, albumin as well as alkaline phosphatase and gamma glutamyl transferase activity were decreased by the extract, those of neutrophil, magnesium, total and conjugated bilirubin, alanine and aspartate aminotransferase as well as liver and kidney body weight ratios increased.
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19514825 Kazemi A, Sharifi F, Jafari N, Mousavinasab N: High prevalence of vitamin D deficiency among pregnant women and their newborns in an Iranian population. J Womens Health. 2009 Jun;18(6):835-9.

Serum concentrations of calcium, phosphorus, 25 (OH) D and alkaline phosphatase were measured in the samples. 25 (OH) D concentrations <25 nmol/L were considered to be indicative of hypovitaminosis D.
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20336459 Shinjo SK, Bonfa E, de Falco Caparbo V, Pereira RM: Low bone mass in juvenile onset sclerosis systemic: the possible role for 25-hydroxyvitamin D insufficiency. Rheumatol Int. 2010 Mar 25.

Laboratorial analysis included autoantibodies, 25-hydroxyvitamin D (25OHD), intact parathyroid hormone, calcium, phosphorus, alkaline phosphatase and albumin sera levels.
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19360617 Ange-van Heugten K, Verstegen M, Ferket PR, Stoskopf M, van Heugten E: Serum chemistry concentrations of captive woolly monkeys (Lagothrix lagotricha). Zoo Biol. 2008 May;27(3):188-99.

All panel result means were similar to previously reported concentrations for howler (Alouatta sp.) and spider monkeys (Ateles sp.) with the possible exception of alanine aminotransferase and gamma-glutamyl-transferase being higher, whereas creatinine and phosphorus were lower.
Alkaline phosphatase (ALP), alanine aminotransferase, and sodium (Na) were higher in females and magnesium (Mg) was higher in males (P <0.05).
1(0,0,0,1) Details
19919972 Aboyade O, Yakubu M, Grierson D, Afolayan A: Studies on the toxicological effect of the aqueous extract of the fresh, dried and boiled berries of Solanum aculeastrum Dunal in male Wistar rats. Hum Exp Toxicol. 2009 Dec;28(12):765-75. Epub .

The DB and BDB increased the serum alkaline phosphatase (ALP) activity whereas FB decreased the activity of the enzyme.
The FB and BFB also increased the levels of potassium, magnesium and phosphorus of the animals.
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19602277 Bozzetti V, Tagliabue P: Metabolic Bone Disease in preterm newborn: an update on nutritional issues. Ital J Pediatr. 2009 Jul 14;35(1):20.

Prematurely born infants are deprived of the intrauterine supply of minerals affecting bone mineralization.The aetiology is multifactorial: inadequate nutrients intake (calcium, phosphorus and vitamin D), a prolonged period of total parenteral nutrition, immobilisation and the intake of some drugs.The diagnosis of metabolic bone disease is done by biochemical analysis: low serum levels of phosphorus and high levels of alkaline phosphatase are suggestive of metabolic bone disease.
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19827189 Berezhnova IA, Korshunov GV: [Plasma lipids and interleukins in geriatric patients with ischemic heart disease]. Klin Lab Diagn. 2009 Aug;(8):3-6.

The serum levels of total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, apoA- and apoB-lipoproteins, calcium, phosphorus, alkaline phosphatase, etc. were measured on a Vitalab Flexor E. biochemical analyzer.
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20004751 Sethuraman S, Nair LS, El-Amin S, Nguyen MT, Singh A, Krogman N, Greish YE, Allcock HR, Brown PW, Laurencin CT: Mechanical properties and osteocompatibility of novel biodegradable alanine based polyphosphazenes: Side group effects. Acta Biomater. 2009 Dec 24.

Moreover, cells on the surface of the polymers expressed type I collagen, alkaline phosphatase, osteocalcin, osteopontin, and bone sialoprotein, which are characteristic genes for osteoblast maturation, differentiation, and mineralization.
Biodegradable polyphosphazenes are high-molecular-weight polymers with alternating nitrogen and phosphorus atoms in the backbone.
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20118415 Letourneau-Montminy MP, Narcy A, Magnin M, Sauvant D, Bernier JF, Pomar C, Jondreville C: Effect of reduced dietary calcium concentration and phytase supplementation on calcium and phosphorus utilization in weanling pigs with modified mineral status. J Anim Sci. 2010 Jan 29.

The animals fed the DD- diet had signs of P deficiency with reduced plasma P (13%; P < 0.01) and femur ash concentration (8%; P < 0.05), and increased plasma Ca (9%; P < 0.05) and alkaline phosphatase activity (31%; P < 0.01).
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19620198 Huh SY, Feldman HA, Cox JE, Gordon CM: Prevalence of transient hyperphosphatasemia among healthy infants and toddlers. Pediatrics. 2009 Aug;124(2):703-9. Epub 2009 Jul 20.

We measured serum levels of alkaline phosphatase (AP), 25-hydroxyvitamin D, parathyroid hormone (PTH), calcium, magnesium, and phosphorus.
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19774112 Prakash D, Behari J: Synergistic role of hydroxyapatite nanoparticles and pulsed electromagnetic field therapy to prevent bone loss in rats following exposure to simulated microgravity. Int J Nanomedicine. 2009;4:133-44. Epub 2009 Sep 10.

In order to compare the resulting changes, mineralogical (bone mineral density [BMD], calcium [Ca], and phosphorus [P]), biochemical (osteocalcin, alkaline phosphatase [ALP], and type I collagen), and histological (scanning electron microscopy) parameters were adopted.
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19760629 Isahaya E, Hara N, Nishiyama T, Hoshii T, Takizawa I, Takahashi K: Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy (ADT): impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis. Prostate. 2010 Feb 1;70(2):155-61.

Bone resorption markers such as blood N-telopeptide (NTx), urinary NTx, calcium, and inorganic phosphorus levels increased after ADT (P < 0.001 in all).
The ratio of the IGF-1 level after ADT/before ADT was associated with the ratio of the value after ADT/before ADT of alkaline phosphatase (rs = 0.266, P = 0.025) and calcium (rs = 0.242, P = 0.042).
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19404704 Conti-Freitas LC, Foss-Freitas MC, Lucca LJ, da Costa JA, Mamede RC, Foss MC: Dynamics of parathyroid hormone secretion after total parathyroidectomy and autotransplantation. World J Surg. 2009 Jul;33(7):1403-7.

RESULTS: In RP, there was a decrease in the average serum levels of PTH, phosphorus, and alkaline phosphatase, which ranged from 13 to 231 (87 +/- 65) pg/ml, 2.3 to 6.2 (3.3 +/- 1.1) mg/dl, and 77 to 504 (250 +/- 135) U/L, respectively, similar to that observed in LP.
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19577454 El-Shitany NA, Hegazy S, El-Desoky K: Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats. Phytomedicine. 2010 Feb;17(2):116-25. Epub 2009 Jul 3.

Biochemical markers of bone formation (total alkaline phosphatase (ALP), calcium, phosphorus and osteocalcin), endocrinological analysis (estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH) and parathyroid hormone (PTH)) and serum total cholesterol and total lipids were estimated.
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19531580 Ornsrud R, Lock EJ, Glover CN, Flik G: Retinoic acid cross-talk with calcitriol activity in Atlantic salmon (Salmo salar). J Endocrinol. 2009 Sep;202(3):473-82. Epub 2009 Jun 16.

VA metabolites, CTR, calcium (Ca), magnesium (Mg) and phosphorus (P) were determined in plasma.
Expression of bone matrix Gla protein (mgp), collagen 1 alpha2 chain (col1a2) and alkaline phosphatase (alp) mRNA was quantified to reflect osteogenesis.
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19762818 Battacone G, Nudda A, Palomba M, Mazzette A, Pulina G: The transfer of aflatoxin M1 in milk of ewes fed diet naturally contaminated by aflatoxins and effect of inclusion of dried yeast culture in the diet. J Dairy Sci. 2009 Oct;92(10):4997-5004.


Blood serum parameters (creatinine, glutamic oxalacetic transaminase, glutamic pyruvic transaminase, gamma glutamyl transferase, alkaline phosphatase, lactate dehydrogenase, cholesterol, protein, urea, calcium, and phosphorus) were not influenced by AFB1 intake.
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20093006 Xie C, Lu R, Huang Y, Wang Q, Xu X: Effects of ions and phosphates on alkaline phosphatase activity in aerobic activated sludge system. Bioresour Technol. 2010 May;101(10):3394-9. Epub 2010 Jan 25.

However, phosphorus especially pyrophosphate had an inhibitory effect on APA, since the residual activity of alkaline phosphatase dramatically decreased to 34.8% of the control at the pyrophosphate concentration of 5.0mM.
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19793187 Lerner RG, Aronow WS, Sekhri A, Palaniswamy C, Ahn C, Singh T, Sandhu R, McClung JA: Warfarin use and the risk of valvular calcification. J Thromb Haemost. 2009 Dec;7(12):2023-7. Epub 2009 Sep 28.

Logistic regression analyses were also conducted to investigate whether the relationship stands after adjustment for confounding risk factors such as age, sex, race, ejection fraction, smoking, hypertension, diabetes, dyslipidemia, coronary artery disease (CAD), glomerular filtration rate, calcium, phosphorus, calcium-phosphorus product, alkaline phosphatase, use of aspirin, beta blockers, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and statins.
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19473331 Tryland M, Lydersen C, Kovacs KM, Thoresen SI: Serum chemistry reference values in free-ranging North Atlantic male walruses (Odobenus rosmarus rosmarus) from the Svalbard archipelago. Vet Clin Pathol. 2009 May 15.

Results: Reference values (ranges) included alanine aminotransferase (12-51 U/L), aspartate aminotransferase (54-137 U/L), alkaline phosphatase (42-243 U/L), creatine kinase (32-506 U/L), lactate dehydrogenase (480-1322 U/L), amylase (0-23 U/L), lipase (68-298 U/L), total protein (68-91 g/L), albumin (25.3-34.8 g/L), creatinine (84-137 mumol/L), urea (8.2-19.9 mmol/L), bilirubin (0-4 mumol/L), cholesterol (4.4-7.3 mmol/L), NEFA (0.1-0.4 mmol/L), triglycerides (0.6-2.2 mmol/L), calcium (2.0-2.7 mmol/L), phosphorus (1.7-2.8 mmol/L), sodium (147-162 mmol/L), potassium (4.7-7.4 mmol/L), chloride (102-115 mmol/L), and cortisol (<28-214 nmol/L).
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19617501 Foster GW, Cunningham MW: Hematology and serum chemistry values for free-ranging Florida panther neonates with a comparison to adult panther values. J Wildl Dis. 2009 Jul;45(3):857-62.

Neonates had higher mean serum values of total bilirubin, alkaline phosphatase, cholesterol, calcium, phosphorus, triglycerides, and magnesium than adult panthers but lower mean values of urea nitrogen, creatinine, total protein, albumin, alanine aminotransferase, aspartate aminotransferase, sodium, chloride, creatine kinase, amylase, and total globulin.
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19504563 Cobanoglu N, Atasoy H, Ozcelik U, Yalcin E, Dogru D, Kiper N, Gocmen A: Relation of bone mineral density with clinical and laboratory parameters in pre-pubertal children with cystic fibrosis. Pediatr Pulmonol. 2009 Jul;44(7):706-12.

After anthropometric measurements, BMD, serum calcium, phosphorus, total alkaline phosphatase (ALP), 25-hydroxy vitamin D (25-OHD), parathyroid hormone, osteocalcin, tumor necrosis factor (TNF)-alpha, soluble TNF-alpha receptor 2 (sTNFR2), and soluble IL-2 receptor (sIL-2R) levels, and urinary calcium and hydroxyproline excretions were assessed.
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19735182 Afolayan AJ, Yakubu MT: Effect of Bulbine natalensis Baker stem extract on the functional indices and histology of the liver and kidney of male Wistar rats. J Med Food. 2009 Aug;12(4):814-20.

While the extract increased the activities of liver gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), alanine and aspartate aminotransferase (ALT and AST, respectively), and total bilirubin, globulin, and urea, the levels of albumin, conjugated bilirubin, inorganic phosphorus, and kidney ALP and GGT decreased.
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19617496 Gelli D, Ferrari V, Franceschini F, Lai O, Laricchiuta P, Zanella A, Bernardini D, Romagnoli S: Serum biochemistry and electrophoretic patterns in the Eurasian Buzzard (Buteo buteo): reference values. J Wildl Dis. 2009 Jul;45(3):828-33.

Mean values for biochemistry parameters were pancreatic amylase 626.9 IU/l, uric acid 7.5 mg/dl, aspartate aminotransferase 330.9 IU/l, glucose 375.1 mg/dl, lipase 26.3 IU/ l, total protein 38.4 g/l, total bilirubin 0.04 mg/ dl, lactate dehydrogenase 2,008.4 IU/l, creatinine kinase 1,604.1 IU/l, alanine aminotransferase 40.4 IU/l, alkaline phosphatase 89.8 IU/l, magnesium 2.3 mg/dl, calcium 10.2 mg/dl, phosphorus 2.02 mg/dl, cholesterol 192.2 mg/ dl, triglyceride 116.4 mg/dl, albumin 14.5 g/l, creatinine 0.1 mg/dl.
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20219254 Orhan E, Erol S, Deren O, Sevin A, Ekici O, Erdogan B: Idiopathic bilateral central giant cell reparative granuloma of jaws: A case report and literature review. Int J Pediatr Otorhinolaryngol. 2010 Mar 8.

Blood chemistry, including calcium, alkaline phosphatase and inorganic phosphorus was normal.
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19709912 Flint M, Morton JM, Limpus CJ, Patterson-Kane JC, Murray PJ, Mills PC: Development and application of biochemical and haematological reference intervals to identify unhealthy green sea turtles (Chelonia mydas). Vet J. 2009 Aug 24.

All of the unhealthy animals had plasma biochemical and haematological values outside one or more RIs (albumin, 48% of unhealthy animals; alkaline phosphatase, 35%; aspartate transaminase, 13%; creatinine, 30%; globulin, 3%; glucose, 34%; lactic dehydrogenase, 26%; phosphorus, 22%; sodium, 13%; thrombocytes, 57%; and monocytes, 5%).
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19690769 Lazar M, Ion DA, Streinu-Cercel A, Badarau AI: Fahr's syndrome: diagnosis issues in patients with unknown family history of disease. Rom J Morphol Embryol. 2009;50(3):425-8.


All the patients were evaluated by CT-scans and levels of serum calcium and alkaline phosphatase were measured in cases with cerebral calcification, in order to exclude abnormal calcium-phosphorus metabolism.
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19932904 Cheng SP, Yang TL, Lee JJ, Chen HH, Wu CJ, Liu TP, Liu CL: Gender Differences Among Patients with Secondary Hyperparathyroidism Undergoing Parathyroidectomy. J Surg Res. 2009 Aug 22.


No differences in preoperative calcium-phosphorus product, alkaline phosphatase, or parathyroid hormone levels were observed.
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20020207 Gulati A, Sridhar V, Bose T, Hari P, Bagga A: Short-term efficacy of sevelamer versus calcium acetate in patients with chronic kidney disease stage 3-4. Int Urol Nephrol. 2009 Dec 18.

The effect of therapy was adjusted for baseline blood levels of calcium, phosphorus, calcium-phosphate product, alkaline phosphatase, PTH and GFR using ANOVA.
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19729429 Beddhu S, Ma X, Baird B, Cheung AK, Greene T: Serum alkaline phosphatase and mortality in African Americans with chronic kidney disease. Clin J Am Soc Nephrol. 2009 Nov;4(11):1805-10. Epub 2009 Sep 3.

With further adjustment for liver function tests as well as serum calcium and phosphorus, each doubling of serum alkaline phosphatase remained significantly associated with increased mortality (HR 1.55, 95% CI 1.03 to 2.33).
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19639269 Li C, Jiang Z, Liu X: Biochemical mechanism of gallium on prevention of fatal cage-layer osteoporosis. Biol Trace Elem Res. 2010 May;134(2):195-202. Epub 2009 Jul 29.

Serum calcium and phosphorus, serum alkaline phosphatase, tartrate resistant acid phosphatase (TRAP), serum osteocalcin, homocysteine, C-terminal crosslinked telopeptides of collagen type I, and bone mineral content were measured, respectively.
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20226604 Yokoyama K, Takahashi N, Yada Y, Koike Y, Kawamata R, Uehara R, Kono Y, Honma Y, Momoi MY: Prolonged maternal magnesium administration and bone metabolism in neonates. Early Hum Dev. 2010 Mar;86(3):187-91. Epub 2010 Mar 12.

Neonatal serum levels of magnesium (Mg), calcium (Ca), phosphorus (P) and alkaline phosphatase (ALP) were reviewed.
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20199720 Zhang J, Wang KX, Wei Y, Xu MH, Su JM, Bao YG, Zhao SY: [Effect of topiramate and carbamazepine on bone metabolism in children with epilepsy.]. Zhongguo Dang Dai Er Ke Za Zhi. 2010 Feb;12(2):96-8.

Biochemical indices of bone metabolism, including serum calcium, phosphorus and alkaline phosphatase contents were measured.
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19339410 Bugeja A, Dacouris N, Thomas A, Marticorena R, McFarlane P, Donnelly S, Goldstein M: In-center nocturnal hemodialysis: another option in the management of chronic kidney disease. Clin J Am Soc Nephrol. 2009 Apr;4(4):778-83. Epub 2009 Apr 1.

RESULTS: After conversion to INHD, median values for phosphorus decreased from 5.9 to 3.7 mg/dl (P < 0.01), alkaline phosphatase level increased from 84 to 161 U/L (P < 0.01), and percentage reduction in urea increased from 74 to 89% (P < 0.01).
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19337166 Tantawy AA, El Kholy M, Moustafa T, Elsedfy HH: Bone mineral density and calcium metabolism in adolescents with beta-thalassemia major. Pediatr Endocrinol Rev. 2008 Oct;6 Suppl 1:132-5.

Bone mineral density (BMD) at both the lumbar spine and femoral neck was measured in 40 adolescents with beta thalassemia major (TM) by DXA scanning and correlated to biochemical parameters including calcium, phosphorus, alkaline phosphatase, bone alkaline phosphatase, intact parathyroid hormone and 25-OH vitamin D as well as vitamin D receptor (VDR) gene polymorphisms at exon 2 (Fok1).
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20062904 Mahdy S, Al-Emadi SA, Khanjar IA, Hammoudeh MM, Sarakbi HA, Siam AM, Abdelrahman MO: Vitamin D status in health care professionals in Qatar. Saudi Med J. 2010 Jan;31(1):74-7.

Serum levels of 25-hydroxyvitamin D (25OHD), parathyroid hormone (PTH), calcium, phosphorus, alkaline phosphatase, total protein, and albumin were obtained.
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19390788 Sandhu R, Lal H, Kundu ZS, Kharb S: Serum Fluoride and Sialic Acid Levels in Osteosarcoma. . Biol Trace Elem Res. 2009 Apr 24.

The present study was planned to analyze serum fluoride, sialic acid, calcium, phosphorus, and alkaline phosphatase levels in 25 patients of osteosarcoma and age- and sex-matched subjects with bone-forming tumours other than osteosarcoma and musculo-skeletal pain (controls, 25 each).
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19715931 Torregrosa JV, Bergua C, Martinez de Osaba MJ, Oppenheimer F, Campistol JM: Evolution of secondary hyperparathyroidism after kidney transplantation in patients receiving cinacalcet on dialysis. Transplant Proc. 2009 Jul-Aug;41(6):2396-8.

Creatinine, calcium, phosphorus, alkaline phosphatase, and iPTH concentrations were evaluated at baseline (day of surgery), at 15 days after surgery, and then monthly for 6 months.
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19793224 Sachdeva R, Soora R, Bryant JC, Seibert JJ, Blaszak RT, Frazier EA: Bone mineral status in pediatric heart transplant recipients: A retrospective observational study of an "at risk" cohort. Pediatr Transplant. 2009 Sep 28.

Data collected included patient demographics, BMD evaluations, serum calcium, phosphorus, alkaline phosphatase, cumulative steroid dose, osseous complications and their management.
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20004756 Biino G, Casula L, de Terlizzi F, Adamo M, Vaccargiu S, Francavilla M, Loi D, Casti A, Atzori M, Cosso M, Marras F, Cepollaro C, Brandi ML, Pirastu M: Genetic architecture of hand quantitative ultrasound measures: a population-based study in a Sardinian genetic isolate. Bone. 2010 Apr;46(4):1197-203. Epub 2009 Dec 30.

These phenotypes were first regressed on age, anthropometric and bioimpedance measures, serum calcium, phosphorus and alkaline phosphatase, alcohol and caffeine consumption, smoking status, exercise and also months since menopause and estrogens use in women.
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20090014 Moen R, Rasmussen JM, Burdett CL, Pelican KM: Hematology, serum chemistry, and body mass of free-ranging and captive Canada lynx in Minnesota. J Wildl Dis. 2010 Jan;46(1):13-22.

Alkaline phosphatase and phosphorus were higher in juveniles (<12 mo when captured) as compared to adults.
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20052352 Kim MJ, Na B, No SJ, Han HS, Jeong EH, Lee W, Han Y, Hyeun T: Nutritional status of vitamin D and the effect of vitamin D supplementation in Korean breast-fed infants. J Korean Med Sci. 2010 Jan;25(1):83-9. Epub 2009 Dec 26.

We measured serum concentrations of vitamin D (25OHD3), calcium (Ca), phosphorus (P), alkaline phosphatase (AP), intact parathyroid hormone (iPTH) and bone mineral density (BMD) at 6 and 12 months of age.
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19689775 Navarro-Rodenas A, Morte A, Perez-Gilabert M: Partial purification, characterisation and histochemical localisation of alkaline phosphatase from ascocarps of the edible desert truffle Terfezia claveryi Chatin. Plant Biol. 2009 Sep;11(5):678-85.

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19501906 Osathanon T, Giachelli CM, Somerman MJ: Immobilization of alkaline phosphatase on microporous nanofibrous fibrin scaffolds for bone tissue engineering. Biomaterials. 2009 Sep;30(27):4513-21. Epub 2009 Jun 6.

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20038659 McCarthy SD, Rafferty SP, Frost PC: Responses of alkaline phosphatase activity to phosphorus stress in Daphnia magna. J Exp Biol. 2010 Jan;213(Pt 2):256-61.
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19718820 Berezhnova IA, Korshunov GV: [Biochemical markers of bone resorption and formation in geriatric patients with ischemic heart disease and osteoporosis]. Klin Lab Diagn. 2009 Jul;(7):3-7.

The serum levels of total cholesterol, triglycerides, high-density lipoproteins, low-density lipoproteins, apoA- and apoB-lipoproteins, calcium, phosphorus, alkaline phosphatase, etc. were measured on a Vitalab Flexor E. biochemical analyzer.
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20011837 Carvalho M, Freitas Filho LG, Carvalho M, Fagundes DJ, Ortiz V: Effects of repeated extracorporeal shock wave in urinary biochemical markers of rats. Acta Cir Bras. 2009 Nov-Dec;24(6):496-501.

The ph, creatinine, sodium, potassium, chlorides, calcium, magnesium, phosphorus, oxalates, alkaline phosphatase and citrates were measured.
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19434468 Lim YW, Kwon SY, Sun DH, Kim HE, Kim YS: Enhanced cell integration to titanium alloy by surface treatment with microarc oxidation: a pilot study. Clin Orthop Relat Res. 2009 Sep;467(9):2251-8. Epub 2009 May 12.

Microarc oxidation (MAO) is a surface treatment that provides nanoporous pits, and thick oxide layers, and incorporates calcium and phosphorus into the coating layer of titanium alloy.
Biologic and morphologic responses to osteoblast cell lines (SaOS-2) were then examined by measuring cell proliferation, cell differentiation (alkaline phosphatase activity), and alpha v beta 3 integrin.
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20305510 Cecchetti DF, Paula SA, Cruz AA, Lucca L Jr, Nogueira-Barbosa MH, Chahud F, Conti-Freitas LC, Melo CB: Orbital involvement in craniofacial brown tumors. Ophthal Plast Reconstr Surg. 2010 Mar-Apr;26(2):106-11.

Laboratory results such as serum levels of alkaline phosphatase, calcium, phosphorus, and parathyroid hormone were recorded.
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19576150 Billoo AG, Murtaza G, Memon MA, Khaskheli SA, Iqbal K, Rao MH: Comparison of oral versus injectable vitamin-D for the treatment of nutritional vitamin-D deficiency rickets. J Coll Physicians Surg Pak. 2009 Jul;19(7):428-31.

Phosphorus, alkaline phosphatase and X-ray of wrist joint were done.
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19921089 Kanakamani J, Tomar N, Kaushal E, Tandon N, Goswami R: Presence of a deletion mutation (c.716delA) in the ligand binding domain of the vitamin D receptor in an Indian patient with vitamin D-dependent rickets type II. Calcif Tissue Int. 2010 Jan;86(1):33-41. Epub 2009 Nov 17.

After 18 months of treatment, she gained 6 cm of height, serum calcium and phosphorus improved, alkaline phosphatase levels decreased, and intact PTH normalized.
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19766303 Ivancic I, Fuks D, Radic T, Lyons DM, Silovic T, Kraus R, Precali R: Phytoplankton and bacterial alkaline phosphatase activity in the northern Adriatic Sea. Mar Environ Res. 2010 Mar;69(2):85-94. Epub 2009 Aug 27.

During late spring and summer both communities exploited dissolved organic phosphorus although, taking into account biomass, phytoplankton activity usually dominated over bacterial activity.
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19640269 Mitchell SM, Rogers SP, Hicks PD, Hawthorne KM, Parker BR, Abrams SA: High frequencies of elevated alkaline phosphatase activity and rickets exist in extremely low birth weight infants despite current nutritional support. BMC Pediatr. 2009 Jul 29;9:47.

RESULTS: In this cohort of 113 infants, P-APA was found to have a significant inverse relationship with BW, gestational age and serum phosphorus.
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20308769 Marwaha RK, Tandon N, Agarwal N, Puri S, Agarwal R, Singh S, Mani K: Impact of Two Regimens of Vitamin D Supplementation on Calcium Vitamin D PTH Axis of Schoolgirls of Delhi. Indian Pediatr. 2010 Jan 15. pii: S097475590900056-1.

Outcome measure: Serum 25 (OH) D, calcium, phosphorus, parathyroid hormone, and alkaline phosphatase levels at 6 and 12 months after start of supplementation.
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19537011 Bahlous A, Farjallah N, Bouzid K, Klouz A, Mohsni A, Sahli H, Lakhal M, Sallami S, Abdelmoula J: Hypovitaminosis D in Tunisian osteoporotic postmenopausal women and the relationship with bone fractures. Tunis Med. 2009 Mar;87(3):188-90.

We measured calcium, phosphorus, albumin, alkaline phosphatase, creatinine and 25 hydroxyvitamin D [25 (OH) vit D].
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19713297 Moore C, Yee J, Malluche H, Rao DS, Monier-Faugere MC, Adams E, Daramola-Ogunwuyi O, Fehmi H, Bhat S, Osman-Malik Y: Relationship between bone histology and markers of bone and mineral metabolism in African-American hemodialysis patients. Clin J Am Soc Nephrol. 2009 Sep;4(9):1484-1493.

At the time of biopsy, mean corrected calcium was 9.1, 8.9, and 9.4 mg/dl (P = 0.344); calcium-phosphorus (Ca X PO4) product was 42, 55, and 62 mg (2)/dl (2) (P = 0.002); phosphorus was 4.6, 6.2, and 6.7 mg/dl (P = 0.005); and iPTH was 225, 566, and 975 pg/ml (P = 0.006), respectively.
Median values for bone-specific alkaline phosphatase (BS-AP) were 16, 34, and 64 ng/ml (P < 0.0001) among the three groups.
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19425583 Lopez-Canut V, Marti S, Bertran J, Moliner V, Tunon I: Theoretical modeling of the reaction mechanism of phosphate monoester hydrolysis in alkaline phosphatase. J Phys Chem B. 2009 Jun 4;113(22):7816-24.

A recently developed semiempirical Hamiltonian, AM1/d-PhoT, which takes into account the d orbitals on the phosphorus atom, has been employed.
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19491914 Jain N, Weinstein RS: Giant osteoclasts after long-term bisphosphonate therapy: diagnostic challenges. Nat Rev Rheumatol. 2009 Jun;5(6):341-6.

INVESTIGATIONS: Bone mineral density determinations, measurement of serum 25-hydroxyvitamin D, intact parathyroid hormone, calcium, inorganic phosphorus, alkaline phosphatase and creatinine levels, urinary excretion levels of the N-telopeptide of type 1 collagen, and bone biopsy.
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19571528 Premaor MO, Scalco R, da Silva MJ, Furlanetto TW: Secondary hyperparathyroidism is associated with increased risk of hospitalization or death in elderly adults living in a geriatric institution. Gerontology. 2009;55(4):405-10. Epub 2009 Jul 2.

Serum levels of 25-hydroxyvitamin D [25 (OH) D], parathyroid hormone (PTH), albumin, total calcium, phosphorus, magnesium, creatinine and alkaline phosphatase were measured.
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19968104 Lu N, Hu WP, Deng JC, Zhai SH, Chen XM, Zhou XP: [Spatial distribution characteristics and ecological significance of alkaline phosphatase in water column of Taihu Lake]. Huan Jing Ke Xue. 2009 Oct 15;30(10):2898-903.

The value of Km from the grass type zone of Taihu Lake was the highest (20.50 +/- 11.30) micromol x L (-1) , and the one from estuary zone in western bank of Taihu Lake was the lowest (9.17 +/- 3.46) micromol x L (-1) The value of kinetic parameter Vmax was significantly positively correlated with the values of pH, total phosphorus (TP) and the chlorophyll a (Chla), with r (pH) = 0.6512** (p < 0.01), r (TP) = 0.4885** (p < 0.01) and r (Chla) = 0.7656** (p < 0.01), respectively.
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20016710 Choi MJ: Effects of taurine supplementation on bone mineral density in ovariectomized rats fed calcium deficient diet. Nutr Res Pract. 2009 Summer;3(2):108-13. Epub 2009 Jun 30.

The serum and urine concentrations of calcium and phosphorus were determined.
Bone formation was measured by serum osteocalcin and alkaline phosphatase (ALP) concentrations.
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