Protein Information

Name albumin
Synonyms ALB; Albumin; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619…

Compound Information

Name antu
CAS 1-naphthalenylthiourea

Reference List

PubMed Abstract RScore(About this table)
18344105 Hantson P, Bernard A, Hermans C: Kinetics and determinants of the changes of CC16, a lung secretory protein in a rat model of toxic lung injury. Clin Toxicol. 2008 Mar;46(3):230-8.

RESULTS: Bronchiolar insult due to IPO or ANTU resulted in an initial transient increase of serum CC16, parallel to that of albumin in BALF, and a subsequent reduction in both BALF and serum.
32(0,1,1,2) Details
18712897 Wu YW, Tsai YH: Characterization of and mechanism for copper-induced thioureation of serum albumin. Bioconjug Chem. 2008 Sep;19(9):1822-30. Epub 2008 Aug 20.

This study demonstrated that copper induced the disulfide-linkage between Tus, such as alpha-naphthylthiourea (ANTU) and fluorescein-5-isothiocyanate cadaverine (FTC), with albumin (Alb), a major carrier protein in plasma with multiple functions.
31(0,1,1,1) Details
9154891 Guery BP, Mason CM, Dobard EP, Beaucaire G, Summer WR, Nelson S: Keratinocyte growth factor increases transalveolar sodium reabsorption in normal and injured rat lungs. Am J Respir Crit Care Med. 1997 May;155(5):1777-84.

Albumin space measurements showed similar increases in permeability in the PBS/ANTU and KGF/ANTU groups.
6(0,0,1,1) Details
7735616 Dreyfuss D, Soler P, Saumon G: Mechanical ventilation-induced pulmonary edema. Am J Respir Crit Care Med. 1995 May;151(5):1568-75.

ANTU alone produced moderate permeability edema with significant increases in extravascular lung water (Qwl), dry lung weight (DLW), and albumin distribution space in lungs (ASp).
6(0,0,1,1) Details
10414398 Hermans C, Knoops B, Wiedig M, Arsalane K, Toubeau G, Falmagne P, Bernard A: Clara cell protein as a marker of Clara cell damage and bronchoalveolar blood barrier permeability. Eur Respir J. 1999 May;13(5):1014-21.

Female Sprague-Dawley rats were given a single i.p. injection of arachis oil (n=20) or chemicals in arachis oil (n=10) that mainly damage Clara cells (4-ipomeanol (IPO) 8 mg x kg (-1) and methylcyclopentadienyl manganese tricarbonyl (MMT) 5 mg x kg (-1)) or endothelial cells (alpha-naphthylthiourea (ANTU) 5 mg x kg (-1)).
This rise of CC16 in serum was associated with an elevation of albumin in BALF which is an index of increased bronchoalveolar/blood barrier permeability.
1(0,0,0,1) Details
9729556 Guery BP, Nelson S, Viget N, Fialdes P, Summer WR, Dobard E, Beaucaire G, Mason CM: Fluorescein-labeled dextran concentration is increased in BAL fluid after ANTU-induced edema in rats. J Appl Physiol. 1998 Sep;85(3):842-8.

Consistent results were observed with the radioactive tracers: there was an increase in extravascular albumin space and extravascular lung water compared with the control group.
1(0,0,0,1) Details