Protein Information

Name CC16
Synonyms Blastokinin; CC10; CC16; CCPBP; CCSP; Clara cell phospholipid binding protein; Clara cell secretory protein; Clara cell specific 10 kDa protein…

Compound Information

Name antu
CAS 1-naphthalenylthiourea

Reference List

PubMed Abstract RScore(About this table)
10414398 Hermans C, Knoops B, Wiedig M, Arsalane K, Toubeau G, Falmagne P, Bernard A: Clara cell protein as a marker of Clara cell damage and bronchoalveolar blood barrier permeability. Eur Respir J. 1999 May;13(5):1014-21.

CC16 concentration (mean+/-sD in microg x L (-1)), measured by a sensitive latex immunoassay, was significantly reduced in BALF of all treated groups (IPO 380+/-100; MMT 730+/-200; ANTU 1,070+/-200; controls 1,700+/-470).
40(0,1,2,5) Details
18344105 Hantson P, Bernard A, Hermans C: Kinetics and determinants of the changes of CC16, a lung secretory protein in a rat model of toxic lung injury. Clin Toxicol. 2008 Mar;46(3):230-8.

RESULTS: Bronchiolar insult due to IPO or ANTU resulted in an initial transient increase of serum CC16, parallel to that of albumin in BALF, and a subsequent reduction in both BALF and serum.
37(0,1,1,7) Details
9517618 Hermans C, Lesur O, Weynand B, Pieters T, Lambert M, Bernard A: Clara cell protein (CC16) in pleural fluids: a marker of leakage through the visceral pleura. Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):962-9.

CC16 was also studied in serum and PF of normal rats and in rats with pleural exudate induced by alpha-naphthyl-thiourea (ANTU).
18(0,0,2,8) Details