| Name | triosephosphate isomerase |
|---|---|
| Synonyms | D glyceraldehyde 3 phosphate keto isomerase; TIM; TPI; TPI 1; TPI1; Triose phosphate isomerase; Triosephosphate isomerase; Triosephosphate isomerase 1… |
| Name | α-chlorohydrin |
|---|---|
| CAS | 3-chloro-1,2-propanediol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 9702787 | Sheline CT, Choi DW: Neuronal death in cultured murine cortical cells is induced by inhibition of GAPDH and triosephosphate isomerase. Neurobiol Dis. 1998 Jul;5(1):47-54. |
2(0,0,0,2) | Details |
| 629780 | Brown-Woodman PD, Mohri H, Mohri T, Suter D, White IG: Mode of action of alpha-chlorohydrin as a male anti-fertility agent. Biochem J. 1978 Jan 15;170(1):23-37. After incubation with 3mm-alpha-chlorohydrin, glyceraldehyde 3-phosphate dehydrogenase and triose phosphate isomerase activities were decreased by approx. 90% and 80% respectively, and in some experiments aldolase was also inhibited. |
2(0,0,0,2) | Details |
| 7277334 | Ford WC, Harrison A, Waites GM: Effects of 6-chloro-6-deoxysugars on oxidation in rat spermatozoa. . J Reprod Fertil. 1981 Sep;63(1):67-73. oxidation appeared to be inhibited at the triose phosphate isomerase or glyceraldehyde 3-phosphate dehydrogenase reaction. |
1(0,0,0,1) | Details |
| 11012786 | Bone W, Cooper TG: In vitro inhibition of rat cauda epididymal sperm glycolytic enzymes by ornidazole, alpha-chlorohydrin and 1-chloro-3-hydroxypropanone. Int J Androl. 2000 Oct;23(5):284-93. The dose-dependent inhibition in vitro of the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and triosephosphate isomerase (TPI) of distal cauda epididymal rat spermatozoa by (R)-, (S)- and (R,S)-ornidazole (ORN), (R,S)-alpha-chlorohydrin (ACH) and 1-chloro-3-hydroxypropanone (CHOP) was compared. |
1(0,0,0,1) | Details |
| 8848575 | Jones AR, Porter LM: Inhibition of glycolysis in boar spermatozoa by alpha-chlorohydrin appears to be mediated by phosphatase activity. Reprod Fertil Dev. 1995;7(5):1089-94. The high phosphatase activity hydrolyses the ester to alpha-chlorohydrin which undergoes oxidation to (S)-3-chlorolactaldehyde, a specific inhibitor of sperm glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase, thereby exhibiting an anti-glycolytic action. |
1(0,0,0,1) | Details |
| 483861 | Jones AR, Mashford PM, Murcott C: The metabolism of 3-amino-1-chloropropan-2-ol in relation to its antifertility activity in male rats. Xenobiotica. 1979 Apr;9(4):253-61. A difference in metabolic rate or route of the isomers may account for their differing physiological activities. 4. (+)- and (-)-aminochloropropanol exhibited identical in vitro inhibitory activities on the glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase and triosephosphate isomerase, and were substrates for monoamine oxidase to equivalent extents. |
1(0,0,0,1) | Details |