Protein Information

Name NA K ATPase
Synonyms (NA+ + K+)ATPase; ATP1A1; ATPase; ATPase Na+/K+ transporting alpha 1 polypeptide; Na (+) K (+) ATPase; Na (+),K (+) ATPase; Na + K + ATPase; Na K + ATPase…

Compound Information

Name sodium cyanide
CAS sodium cyanide (Na(CN))

Reference List

PubMed Abstract RScore(About this table)
9319415 Schwarzbaum P, Bernabeu R, Krumschnabel G, Wieser C: Effect of chemical anoxia on protein kinase C and Na+, K+-ATPase in hepatocytes of goldfish (Carassius auratus) and rainbow trout (Oncorhynchus mykiss). J Exp Biol. 1996;199(Pt 7):1515-21.

PKC and Na+/K+-ATPase activities were measured for up to 90 min in the absence (normoxia) and presence (chemical anoxia) of 2 mmol l-1 sodium cyanide.
8(0,0,1,3) Details
1387578 Matsuda T, Shimizu I, Murata Y, Baba A: Glucose and oxygen deprivation induces a Ca (2+)-mediated decrease in (Na (+)+K+)-ATPase activity in rat brain slices. Brain Res. 1992 Apr 3;576(2):263-70.

5(0,0,0,5) Details
9575966 Schwarzbaum PJ, Frischmann ME, Krumschnabel G, Rossi RC, Wieser W: Functional role of ecto-ATPase activity in goldfish hepatocytes. . Am J Physiol. 1998 Apr;274(4 Pt 2):R1031-8.


Ecto-ATPase activity was inhibited 70% by suramin but was insensitive to inhibitors of transport ATPases.
1(0,0,0,1) Details
6219742 Scully SP, Segel GB, Lichtman MA: Plasma membrane vesicles prepared from unadhered monocytes: characterization of calcium transport and the calcium ATPase. Cell Calcium. 1982 Dec;3(6):515-30.

The membranes, isolated on a sucrose step gradient, had an 18-fold enrichment in Na,K-ATPase, a 29-fold diminution of succinate dehydrogenase activity and were vesicular on transmission electron micrographs.
The ionophore A23187 completely inhibited calcium accumulation while 5 mM sodium cyanide and 10 microM ouabain had no effect.
1(0,0,0,1) Details
4078218 Robinson CP, Baskin SI, Franz DB: The mechanisms of action of cyanide on the rabbit aorta. . J Appl Toxicol. 1985 Dec;5(6):372-7.


Pretreatment of strips of rabbit aorta with 10 (-3) M sodium cyanide reduced contractions to 10 (-8) through 10 (-4) M norepinephrine (NE) added cumulatively.
0(0,0,0,0) Details
3117973 Naoi M, Nagatsu T: Uptake of L-threo-dihydroxyphenylserine into human brain synaptosomes. J Neural Transm. 1987;70(1-2):51-61.

The L-threo-DOPS uptake was inhibited by 2,4-dinitrophenol, sodium cyanide and other uncouplers of oxidative phosphorylation and by ouabain, an inhibitor of Na+, K+-ATPase, indicating that the uptake is coupled to ATP hydrolysis.
81(1,1,1,1) Details
2024638 Colin FC, Schrier SL: Spontaneous endocytosis in human neonatal and adult red blood cells: comparison to drug-induced endocytosis and to receptor-mediated endocytosis. Am J Hematol. 1991 May;37(1):34-40.

The mechanism of the spontaneous endocytosis was explored using different inhibitors: sodium vanadate an inhibitor of ATPases, sodium fluoride which inhibits the generation of ATP and sodium cyanide a potent inhibitor of oxidative phosphorylation.
31(0,1,1,1) Details