Protein Information

Name metallothionein (protein family or complex)
Synonyms Metallothionein; Metallothioneins

Compound Information

Name sulfoxide
CAS 5-[2-(octylsulfinyl)propyl]-1,3-benzodioxole

Reference List

PubMed Abstract RScore(About this table)
17883856 Mocchegiani E: Zinc and ageing: third Zincage conference. Immun Ageing. 2007 Sep 20;4:5.

Zn homeostasis influences development and function of immune cells, activity of stress-related and antioxidant proteins [metallothioneins (MT), chaperones, ApoJ, Poly (ADP-Ribose) polymerase-1 (PARP-1) and Methionione Sulfoxide Reductase (Msr), Superoxide Dismutase (SOD)], and helps to maintain genomic integrity and stability.
31(0,1,1,1) Details
18715149 Cabreiro F, Picot CR, Perichon M, Friguet B, Petropoulos I: Overexpression of methionine sulfoxide reductases A and B2 protects MOLT-4 cells against zinc-induced oxidative stress. Antioxid Redox Signal. 2009 Feb;11(2):215-25.


Here we show that zinc treatment has a pro-antioxidant effect in MOLT-4 cells by inducing the transcription of metallothioneins and positively modulating the activity of the Msr enzymes.
1(0,0,0,1) Details