| 18715785 |
Brown ME, Fitzner JN, Stevens T, Chin W, Wright CD, Boyce JP: Salicylanilides: selective inhibitors of interleukin-12p40 production. . Bioorg Med Chem. 2008 Sep 15;16(18):8760-4. Epub 2008 Jul 17.
Interleukin (IL)-12p40, a subunit component of both IL-12 and IL-23, is being widely studied for its role in inflammatory disease. As part of an effort to profile cellular signaling pathways across different cell types, we report salicylanilide inhibitors of IL-12p40 production in stimulated dendritic cells. Based on a hypothesis that a desirable therapeutic profile is one that could block IL-12p40 but not IL-6 production, we engaged in directed analoging. This resulted in salicylanilides with similar IL-12p40 related potency but enhanced selectivity relative to IL-6 production. |
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