| 3891555 |
Paschin YuV, Bakhitova LM: Mutagenic effects of thiram in mammalian somatic cells. Food Chem Toxicol. 1985 Mar;23(3):373-5.
The dimethylthiocarbamate fungicide thiram has been found to be a potent and direct inducer of point mutations at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster cells in vitro. It also increased the incidence of micronuclei in polychromatic erythrocytes in the bone marrow of mice given a single ip dose of 100 mg/kg. Both the in vitro and the in vivo mutagenic responses were observed with doses of thiram that were cytotoxic. |
6(0,0,1,1) |