Protein Information

ID 1250
Name ATPDase
Synonyms ATPDase; Hb6; ATPDase; CD39; CD39 antigen; Ecto ATP diphosphohydrolase; Ecto apyrase; Lymphoid cell activation antigen…

Compound Information

ID 615
Name sodium azide
CAS sodium azide

Reference

PubMed Abstract RScore(About this table)
8782093 Caprino L, Togna AR, Stella C, Togna G: An in vitro method for evaluating vascular endothelial ADPase activity. J Pharmacol Toxicol Methods. 1996 Jun;35(3):153-7.
Some xenobiotics, known to promote the development of thrombotic phenomena, affect vascular endothelium ADPase, a regulatory enzyme that inactivates vaso- and platelet-active adenine nucleotides. This proposed new experimental approach represents an improved method of evaluation of vascular endothelial ADPase activity which is assessed by measuring, at pre-established times, the degradation rate of exogenous ADP incubated with aortic bovine patches. The ADP dosage was performed by using a spectrophotometric enzymatic assay. Statistical analyses showed that the method is capable of highlighting the linearity of the ADPase activity time-course, thus indicating that the slopes of time-degradation curves of ADP are a valid index for this endothelial ectoenzyme activity. Results obtained with ADPase inhibiting or stimulating agent confirm that this in vitro method is an efficient tool for estimating the ability of xenobiotics or drugs to modify the nonthrombogenic properties of vascular endothelium.
5(0,0,0,5)