| 15271522 |
Ferrer S, Ballesteros R, Sambartolome A, Gonzalez M, Alzuet G, Borras J, Liu M: Syntheses, crystal structures, and oxidative DNA cleavage of some Cu (II) complexes of 5-amino-3-pyridin-2-yl-1,2,4-triazole. J Inorg Biochem. 2004 Aug;98(8):1436-46.
Three new monomeric Cu (II) complexes of 5-amino-3-pyridin-2-yl-1,2,4-triazole (Hapt), [Cu (Hapt)(H (2) O)(2)(SO (4))] (1), [Cu (Hapt)(2)(H (2) O)(NO (3))](NO (3)) (2), and [Cu (Hapt)(2)(NCS-N)](NCS).H (2) O (3), have been prepared and characterized by single crystal X-ray diffraction. One distorted [CuN (2) O (2)+O (')] square-pyramidal (1), one distorted [CuN (3) O+N (')+O (')] octahedral (2), and one distorted [CuN (4)+N (')] intermediate between square-pyramidal and trigonal-bipyramidal (3) coordination configuration were found and are suggested to be due to the chelating nature of the ligand, which interacts with Cu (II) through the N4 (triazole) and N (pyridine) atoms. Spectral properties of these chelates are in accordance with the X-ray structural data. With ascorbate and H (2) O (2) activation, compound 2 exhibits higher nuclease activity than compound 1. The influence on the DNA cleavage process of different scavengers of reactive oxygen species: dimethyl sulfoxide (DMSO), tert-butyl alcohol, sodium azide, 2,2,6,6-tetramethyl-4-piperidone and superoxide dismutase enzyme (SOD), and of the minor groove binder distamycin, is also studied. |
31(0,1,1,1) |