| 6640302 |
Argentieri TM, McArdle JJ: Interaction of the opiate antagonist, naltrexone methyl bromide, with the acetylcholine receptor system of the motor end-plate. Brain Res. 1983 Oct 31;277(2):377-9.
Naltrexone methyl bromide (NMB) caused alterations in both the amplitude and the time course of end-plate currents (EPC) recorded from rat muscle. The amplitudes were significantly lower than control, and the EPC decay was no longer singly exponential. There was also a decrease in the voltage dependence of the peak amplitude and the decay time constant of the EPCs. These findings suggest NMB is blocking the open state of the acetylcholine channel. |
31(0,1,1,1) |