| 18760603 |
Ohta K, Chiba Y, Ogawa T, Endo Y: Promising core structure for nuclear receptor ligands: design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5050-3. Epub 2008 Aug 6.
Novel diphenylamine-type estrogen receptor ligands were designed and synthesized, and their biological activities were evaluated by means of binding assays for estrogen receptor-alpha and -beta and cell proliferation assay using MCF-7 cells. Compounds 4f, 11b, 12c, and 8 showed moderate estrogenic activities. We propose that the diphenylamine skeleton may be a privileged structure for various nuclear receptor ligands, including RAR, RXR, and AR ligands. |
81(1,1,1,1) |