| 19584101 |
Pazynina G, Sablina M, Mayzel M, Nasonov V, Tuzikov A, Bovin N: Chemical synthesis of 6 (GlcNAc)- and 6 (Gal)-O-sulfated SiaLe (X) tetrasaccharides in spacer-armed form. Glycobiology. 2009 Oct;19(10):1078-81. Epub 2009 Jul 7.
Practical synthesis of tetrasaccharide sulfates, 6 ((GlcNAc))-O-Su-SiaLe (X)-OCH (2) CH (2) CH (2) NH (2) and 6 ((Gal))-O-Su-SiaLe (X)-OCH (2) CH (2) CH (2) NH (2) (Su ( ) SO (3) H), selectin ligands, and leu- kocyte trafficking agents is presented. Both sulfates were synthesized starting from the same precursor, protected SiaLe (x), by the conventional procedures of carbohydrate chemistry. The sulfated SiaLe (x) derivative was modified at the spacer group to give 6 ((Gal))-O-Su-SiaLe (x)- OCH (2) CH (2) CH (2) NH-COCH (2) CH (2) C [triple bond] CH, convenient for "click chemistry" mode conjugation with an azido carrier, particularly, for the synthesis of an immunogen. |
31(0,1,1,1) |