| 19284780 |
Meece FA, Jayasinghe C, Histand G, Burns DH: A convenient, one-step synthesis of benzyl (Ar) ureas of the type ArCH (2) NHCONHR from Ar and R (1) OCH (2) NHCONHR via ureidoalkylation. J Org Chem. 2009 Apr 17;74(8):3156-9.
A method for the one-step C-ureidoalkylation of phenol, anisole, or aniline rings furnishing ArCH (2) NHCONHR (Ar = benzyl) products in moderate to good yields is described. With phenol ring systems, higher yields were attained when the reaction was worked up with an acidic ethanethiol addition to cleave any O-ureidoalkylation products that formed during the reaction. |
32(0,1,1,2) |