Protein Information

ID 1769
Name melanoma associated antigen
Synonyms CLL associated antigen KW 1; CLL associated antigen KW 1 splice variant 1; CLL associated antigen KW 1 splice variant 2; Melanoma associated antigen; CLL associated antigen KW 1 splice variant 1s; CLL associated antigen KW 1 splice variant 2s; Melanoma associated antigens

Compound Information

ID 864
Name MAA
CAS methylarsonic acid

Reference

PubMed Abstract RScore(About this table)
11188931 Wang X, Luo W, Ferrone S: Immunotherapy of melanoma: peptide mimics of a human high molecular weight-melanoma associated antigen. Medicina (B Aires). 2000;60 Suppl 2:48-50.
The realization that tumor cells utilize multiple mechanisms to escape from immune recognition and destruction has stimulated interest in developing and applying immunotherapeutic strategies which target both humoral and cellular immunity to malignant cells. As a result, the tumor-associated antigens (TAA) used as targets have to be expressed on the cell surface membrane of malignant cells. Furthermore, since most of the TAA used for active specific immunotherapy are self-antigens, a challenge facing tumor immunologists is to develop strategies which are effective in breaking tolerance to self-antigens. This chapter describes one strategy which relies on the use of peptide mimics of the human high molecular weight-melanoma associated antigen (HMW-MAA) as immunogens to implement active specific immunotherapy in patients with malignant melanoma. These mimics, which are isolated from phage display peptide libraries by panning with anti-HMW-MAA monoclonal antibodies, are expected to induce both humoral and cellular anti-HMW-MAA immunity.
2(0,0,0,2)