| 3243979 |
Castello G, Mansi L, Leonardi E, Lastoria S, Melillo G: Short-term effects of i.v. injected murine 99MTc-F (ab') 2 fragments of an anti-melanoma antibody (HMW-MAA 225.28 S) on haemato-immunological parameters in patients with melanoma. Int J Biol Markers. 1988 Apr-Jun;3(2):140-4.
To evaluate alterations induced by injected murine radiolabelled F (ab') 2 fragments of the anti HMW-MAA MoAb 225.28S on the principal haemato-immunological parameters, 32 patients with advanced malignant melanoma were studied. No statistically significant change was found after MoAb administration, but monocytes (3 h after injection) and granular eosinophils (24 h after) were reduced and circulating immune complexes increased (3 h after). No toxic effect or adverse reaction was observed. Therefore, the controlled administration of purified MoAb fragments for diagnostic purposes seems to involve only a very low risk of immediate adverse reactions. |
2(0,0,0,2) |