| 9238525 |
Kitamura S, Tatsumi K: Menadione-dependent reduction of tertiary amine N-oxide by rat liver cytosol. Biochem Mol Biol Int. 1997 Jun;42(2):271-6.
This study demonstrates the menadione-dependent reduction of imipramine N-oxide, a tertiary amine N-oxide, to imipramine by rat liver cytosol in the presence of NADH or NADPH. A mechanism for the cytosolic reduction of the tertiary amine N-oxide is proposed. Menadione is converted to its reduced form by a menadione-reducing enzyme such as DT-diaphorase and the reduced pyridine nucleotide, followed by reduction of the tertiary amine N-oxide to the amine by the heme group of catalytic hemoproteins in the presence of reduced menadione as an electron donor. |
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