| 1810482 |
Bakalova R, Sokolova Ts, Ribarov S, Kagan V: [The efficiency of the action of alpha-tocopherol and its homologs on luminol-dependent chemiluminescence induced by (Fe2+ + NADP.H) and (Fe2+ + ascorbate) systems in rat liver microsomes]. Biull Eksp Biol Med. 1991 Nov;112(11):482-5.
The effects of alpha-tocopherol (C16) and its homologues with different chain length (6-hydroxychromanes-C1, C6, C11) on lipid peroxidation induced luminol-dependent chemiluminescence in rat liver microsomal suspensions were studied. It was shown that C1, C6 and C11 inhibited the (Fe (2+) + ascorbate)-and (Fe (2+) + NADP.H)-induced chemiluminescence. The inhibitory effect was decreased in the order: C1 C6 C11, C16 was not influenced chemiluminescence. The possible reason underlying these differences was discussed: different efficiency of interaction of C16 and its homologues with hydroxyl and superoxide radicals, which initiate the luminol-dependent chemiluminescence. It was concluded that C16 (in concentration below 0.5 mM) was not interacted with hydroxyl and superoxide free radicals, generated in microsomal suspensions under (Fe (2+) + ascorbate)- and (Fe (2+) + NADP.H)-dependent lipid peroxidation. |
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