| 18439830 |
Massah AR, Adibi H, Khodarahmi R, Abiri R, Majnooni MB, Shahidi S, Asadi B, Mehrabi M, Zolfigol MA: Synthesis, in vitro antibacterial and carbonic anhydrase II inhibitory activities of N-acylsulfonamides using silica sulfuric acid as an efficient catalyst under both solvent-free and heterogeneous conditions. Bioorg Med Chem. 2008 May 15;16(10):5465-72. Epub 2008 Apr 11.
Silica sulfuric acid catalyzes efficiently the reaction of sulfonamides with both carboxylic acid anhydrides and chlorides under solvent-free and heterogeneous conditions. All the reactions were done at room temperature and the N-acylsulfonamides were obtained with high yields and purity via an easy work-up procedure. This method is attractive and is in a close agreement with green chemistry. These compounds were also investigated for antibacterial activity, including Gram-positive cocci and Gram-negative bacilli, and carbonic anhydrase II inhibitory activity. |
81(1,1,1,1) |