| 7761437 |
Guyer D, Patton D, Ward E: Evidence for cross-pathway regulation of metabolic gene expression in plants. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4997-5000.
In Arabidopsis thaliana, blocking histidine biosynthesis with a specific inhibitor of imidazoleglycerol-phosphate dehydratase caused increased expression of eight genes involved in the biosynthesis of aromatic amino acids, histidine, lysine, and purines. A decrease in expression of glutamine synthetase was also observed. Addition of histidine eliminated the gene-regulating effects of the inhibitor, demonstrating that the changes in gene expression resulted from histidine-pathway blockage. These results show that plants are capable of cross-pathway metabolic regulation. |
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