| 1036224 |
Grechishkrin LL, Gavrovskaia LK, Gol'dfarb VL, Brovtsina NB: [H1- and H2-receptor sensitivity to 3-(beta-aminoethyl)-1,2,4-triazole derivatives]. Farmakol Toksikol. 1976 Sep-Oct;39(5):556-60.
Histamine-like derivatives of 3-(beta-aminoethyl)-1,2,4-trizole were synthetized and subjected to a pharmacological study. The sensitivity of H1- and H2-receptors to these substances was defined by the following tests, viz. in the isolated uterus of a rat, on the isolated atrium of a guinea pig and measurements of the blood pressure nn a cat. The derivative 3-(beta-aminoethyl)-5-amino-1,2,4-triazole (IEM-813) affects predominantly H1-receptors, while 3-(aminoethyl)-5-amino-1,2,4,triazole (IEM-759) has the closest affinity for H2-receptors, The authors presume that corresponding zones of histamine recpetors differ in their lyophilic and hydrophilic properties. |
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