| 15780613 |
Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Tavares FX, Willard DH Jr, Wright LL: Novel and potent cyclic cyanamide-based cathepsin K inhibitors. . Bioorg Med Chem Lett. 2005 Apr 1;15(7):1815-9.
Starting from a PDE IV inhibitor hit derived from high throughput screening of the compound collection, a key pyrrolidine cyanamide pharmacophore was identified. Modifications of the pyrrolidine ring produced enhancements in cathepsin K inhibition. An X-ray co-crystal structure of a cyanamide with cathepsin K confirmed the mode of inhibition. |
63(0,2,2,3) |