| 8722703 |
Satoh Y, Gesase AP, Habara Y, Ono K, Kanno T: Lipid secretory mechanisms in the mammalian harderian gland. . Microsc Res Tech. 1996 Jun 1;34(2):104-10.
The mammalian Harderian glands are lipid-secreting glands. In an unstimulated condition, the glandular cells frequently exocytose the lipid materials; however, no intracellular calcium ion ([Ca2+] c) changes are detectable. Cholinergic (muscarinic) secretagogues induce secretory activity and increase of [Ca2+] c. A G-protein activator, sodium fluoride, enhances the secretory activity and increase of [Ca2+] c. Removal of extracellular calcium ions inhibits the secretion enhanced by cholinergic stimulation. Under pharmacologic stimulation, glandular cells may show an apocrine-like secretory pattern. Cholinergic stimulation also induces contraction of the myoepithelial cells covering glandular end pieces; however, the reduction in volume of glandular end pieces is not prominent. Catecholamines have no effect on the release of lipid materials. These results indicate the involvement of G-proteins linking with muscarinic receptors and Ca2+ dynamics (increase of [Ca2+] c and Ca2+ influx) in lipid secretion by glandular cells and in contraction of myoepithelial cells of mammalian Harderian glands. However, the increase of [Ca2+] c in Harderian glands was less when compared with other cells--for instance, those which secrete protein. |
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