| 11860917 |
Zhang C, Liu J, Ling B, Song X, Gu W, Wang G: [The effect of fluoride-arsenic exposure on the lipid peroxidation and antioxidation of the offspring of rats]. Zhonghua Yu Fang Yi Xue Za Zhi. 2000 May;34(3):134-5.
OBJECTIVE: To provide information on the effects of the offspring of rats exposed to fluoride-arsenic. METHODS: The levels of lipid peroxidation and the abilities of antioxidation were determined in the blood of the rats and their offsprings under two generations-one nest reproductive test. RESULTS: The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the blood decreased with the increase of exposure dose. For example, the activity of SOD, was 14.56, 13.74, 11.89 and 11.21 micromol x min (-1) x mg Hb (-1) in different dose groups of F (2), respectively. In contrast, the concentration of lipid peroxides (LPO) increased. Eight weeks after exposure, the activities of SOD and GSH-Px increased, the activity of SOD was 13.97, 13.55, 13.47 and 12.76 micromol x min (-1) x mg Hb (-1), respectively, and the concentration of LPO returned to normal level. CONCLUSION: Fluoride-arsenic exposure can cause oxidative damage of the rat's offspring. |
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