| 11109527 |
Zabrodskii PF, Kirichuk VF, Romashchenko SA, Germanchuk VG: [Effect of the cholinesterase reactivator dipyroxime in various models of delayed hypersensitivity during acute intoxication by acrylonitrile]. Eksp Klin Farmakol. 2000 Sep-Oct;63(5):47-9.
Delayed type hypersensitivity (DTH) response with respect to sheep erythrocytes was studied on various models in CBA mice against the background of acute intoxication with nitrile acrylic acid (NAA). The effect of dipiroxime on the DTH response under these conditions was determined and the relationship of these reactions with the activity of alpha-naphthylbutyratesterase in splenic cells and popliteal lymph nodes was assessed. Dipiroxime partly recovered DTH in various experimental series (except for the reaction of suppressor cell transfer) by restoring the alpha-naphthylbutyratesterase activity in cells of the lymphoid organs studied. |
6(0,0,1,1) |