| 3388448 |
Tandon R, Saxena DK, Chandra SV, Seth PK, Srivastava SP: Testicular effects of acrylonitrile in mice. Toxicol Lett. 1988 Jul;42(1):55-63.
Daily oral administration of acrylonitrile (10 mg/kg body weight) to mice for a period of 60 days caused a significant decrease in the activity of testicular sorbitol dehydrogenase and acid phosphatase, and an increase in that of lactate dehydrogenase and beta-glucuronidase. Histopathological studies revealed degeneration of the seminiferous tubules. A decrease in the sperm counts of the epididymal spermatozoa was also observed in the animals of the acrylonitrile-exposed group. These observations suggest that acrylonitrile may affect the male reproductive function by causing testicular injury. |
6(0,0,1,1) |