| 16105462 |
Wang ZP, Xie KQ, Li HQ: [Effect of carbon disulfide exposure at different phases on the embryonic development in mid-pregnancy of female mice]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Apr;23(2):139-41.
OBJECTIVE: To explore the sensitive point of embryotoxicity of carbon disulphide on female mice. METHODS: At the phases of follicle developing, implanting and post-implantation of blastocyst, female mice were injected intraperitoneally with carbon disulphide 631.4 mg/kg per day for three days while controls with plant oil. All indexes were detected at the fourteenth day of pregnancy. RESULTS: (1) In follicle developing CS (2) exposed group, the weight of embryos fossa [(1.23 +/- 0.36) g was 41% less than that in controls [(2.08 +/- 0.48) g, P = 0.000], and in implanting CS (2) exposed group the weight of embryo fossa, and embryos [(1.27 +/- 0.97) g, and (0.12 +/- 0.09) g respectively] were 39% and 37% less than those in controls [(2.08 +/- 0.48), (0.19 +/- 0.06) g, P = 0.068, P = 0.045]; (2) In both follicle developing and implanting CS (2) exposed group, the weights of uterus and placenta were also less than those in controls (P < 0.01). (3) In post-implantation CS (2) exposed group, the above parameters were not significantly different from those in controls. CONCLUSION: Follicle developing phase as well as implanting of blastocyst may be sensitive point for embryotoxicity induced by carbon disulphide. |
0(0,0,0,0) |