| 8292267 |
Gandhi DN, Venkatakrishna-Bhatt H: Carbon disulphide induced sensitivity changes of rat anococcygeus muscle to noradrenaline (NA). Biomed Environ Sci. 1993 Sep;6(3):223-30.
The sensitivity of rat anococcygeus muscle to noradrenaline (NA) was reduced following carbon disulphide (CS2) pretreatment. Preparations incubated in excess Ca++ (4.2 mmol.L-1) or Zero Ca++ (0.0 mmol.L-1) media showed decrease in sensitivity to NA. Reserpinization failed to induce supersensitivity to NA in any Mg++ concentration in the media. Reserpinized tissue in Mg++ free media with EDTA showed increased sensitivity while decreased sensitivity and maximum response to NA in Mg++ (1.2 mmol.L-1) and excess Mg++ (3.6m mol.L-1) concentration of the medium. In the presence of EDTA, the inhibition observed with CS2 in excess Mg++ (3.6m mol.L-1) medium was comparatively much less in both non-reserpinized and reserpinized preparations. In normal Ca++ and its deficient medium decrease in sensitivity to CS2 and the relevant maximum response to NA were observed. In excess Ca++, the CS2 effect depressed corresponding to its maximal response to NA. Thus CS2 may be inhibiting responses to NA by interfering with Ca++ utilization. |
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